缺血性卒中急性期应用他汀的新证据与新启示

被引:2
作者
王拥军
机构
[1] 首都医科大学附属北京天坛医院神经内科
关键词
他汀类药物; 卒中; 神经保护;
D O I
暂无
中图分类号
R743.3 [急性脑血管疾病(中风)];
学科分类号
1002 ;
摘要
<正>他汀类药物[3-羟基-3-甲基-辅酶A(3-hydroxy-3-methylglutaryl coenzyme A,HMG-CoA)还原酶抑制剂]能有效降低胆固醇并预防冠状动脉粥样硬化性心脏病发病和死亡[1]。2006年强化降低胆固醇预防卒中
引用
收藏
页码:246 / 249
页数:4
相关论文
共 13 条
[1]  
Statin Therapy and Outcome After Ischemic Stroke: Systematic Review and Meta-Analysis of Observational Studies and Randomized Trials[J] . Danielle Ní Chróinín,Kjell Asplund,Signild ?sberg,Elizabeth Callaly,Elisa Cuadrado-Godia,Exuperio Díez-Tejedor,Mario Di Napoli,Stefan T. Engelter,Karen L. Furie,Sotirios Giannopoulos,Antonio M. Gotto,Niamh Hannon,Fredrik Jonsson,Moira K. Kapral,Joan Martí-Fàbregas,Patricia Martínez-Sánchez,Haralampos J. Milionis,Joan Montaner,Antonio Muscari,Slaven Pikija,Jeff
[2]   High-Dose Atorvastatin Enhances Impaired Cerebral Vasomotor Reactivity [J].
Forteza, Alejandro ;
Romano, Jose G. ;
Campo-Bustillo, Iszet ;
Campo, Nelly ;
Haussen, Diogo C. ;
Gutierrez, Jose ;
Koch, Sebastian .
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2012, 21 (06) :487-492
[3]  
The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials[J] . Cholesterol Treatment Trialists’ (CTT) Collaborators.The Lancet . 2012 (9841)
[4]   Statin Use During Ischemic Stroke Hospitalization Is Strongly Associated With Improved Poststroke Survival [J].
Flint, Alexander C. ;
Kamel, Hooman ;
Navi, Babak B. ;
Rao, Vivek A. ;
Faigeles, Bonnie S. ;
Conell, Carol ;
Klingman, Jeff G. ;
Sidney, Stephen ;
Hills, Nancy K. ;
Sorel, Michael ;
Cullen, Sean P. ;
Johnston, S. Claiborne .
STROKE, 2012, 43 (01) :147-154
[5]  
Intravenous administration of pravastatin immediately after middle cerebral artery occlusion reduces cerebral oedema in spontaneously hypertensive rats[J] . Giuseppina Mariucci,Elena Taha,Michela Tantucci,Cristiano Spaccatini,Alessandro Tozzi,Maria Vittoria Ambrosini.European Journal of Pharmacology . 2011 (2)
[6]  
Association Between Acute Statin Therapy, Survival, and Improved Functional Outcome After Ischemic Stroke: The North Dublin Population Stroke Study[J] . Danielle Ní Chróinín,Elizabeth L. Callaly,Joseph Duggan,áine Merwick,Niamh Hannon,órla Sheehan,Michael Marnane,Gillian Horgan,Emma B. Williams,Dawn Harris,Lorraine Kyne,Patricia M.E. McCormack,Joan Moroney,Tim Grant,David Williams,Leslie Daly,Peter J. Kelly.Stroke . 2011 (4)
[7]   Statin Treatment and Stroke Outcome in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Trial [J].
Goldstein, Larry B. ;
Amarenco, Pierre ;
Zivin, Justin ;
Messig, Michael ;
Altafullah, Irfan ;
Callahan, Alfred ;
Hennerici, Michael ;
MacLeod, Mary J. ;
Sillesen, Henrik ;
Zweifler, Richard ;
Welch, K. Michael A. .
STROKE, 2009, 40 (11) :3526-3531
[8]   Additive effects of statin and dipyridamole on cerebral blood flow and stroke protection [J].
Kim, Hyung-Hwan ;
Sawada, Naoki ;
Soydan, Guray ;
Lee, Ho-Seong ;
Zhou, Zhipeng ;
Hwang, Seo-Kyoung ;
Waeber, Christian ;
Moskowitz, Michael A. ;
Liao, James K. .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2008, 28 (07) :1285-1293
[9]  
Statin treatment withdrawal in ischemic stroke: A controlled randomized study[J] . Neurology . 2007 (9)
[10]  
Intermolecular Differences of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Contribute to Distinct Pharmacologic and Pleiotropic Actions[J] . R. Preston Mason,Mary F. Walter,Charles A. Day,Robert F. Jacob.The American Journal of Cardiology . 2005 (5)