脑缺血后脑内血管新生机制

被引：5

作者：

黄绮娟 ^{[1
]}

李龙宣 ^{[1
,2
]}

机构：

[1] 广东医学院附属医院神经内科

[2] 上海市浦东新区公利医院神经科

来源：

国际神经病学神经外科学杂志 | 2014年 / 41卷 / 02期

基金：

广东省自然科学基金;

关键词：

脑缺血; 血管新生; 纤维连接蛋白; 基底膜聚糖; 血管内皮生长因子; 血管生成素。;

D O I：

10.16636/j.cnki.jinn.2014.02.013

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

脑缺血发生后,纤维连接蛋白(Fn)和基底膜聚糖C-端第五功能区(DV)等细胞外基质成分表达增加,与其相应的受体整合素α5β1或αvβ3结合,可引起血管内皮生长因子(VEGF)等生长因子释放增加,从而启动内源性血管新生,促进缺血区血供恢复,挽救濒死的神经元、神经胶质细胞和血管内皮细胞,有利于神经功能恢复。为进一步研究细胞外基质(Fn、DV)-受体整合素-生长因子(VEGF、Ang)通路在脑缺血后血管新生中的机制,现对其最新的相关研究做一综述。

引用

页码：134 / 137

页数：4

共 18 条

[1] 缺氧诱导因子-1α在缺血缺氧脑损伤中的作用研究进展 [J].

胡强 ;

陈高 .

国际神经病学神经外科学杂志, 2013, 40 (03) :258-262

[2] Over-expression of VEGF in marrow stromal cells promotes angiogenesis in rats with cerebral infarction via the synergistic effects of VEGF and Ang-2 [J].

Lai, Tianbao ;

Li, Man ;

Zheng, Lifang ;

Song, Yanling ;

Xu, Xiaoli ;

Guo, Yuanjin ;

Zhang, Yuan ;

Zhang, Zongsheng ;

Mei, Yuanwu .

JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES, 2012, 32 (05) :724-731

[3]

Ectopic expression of human angiopoietin-1 promotes functional recovery and neurogenesis after focal cerebral ischemia[J] . Z. Meng,M. Li,Q. He,S. Jiang,X. Zhang,J. Xiao,Y. Bai.Neuroscience . 2014

[4] Fibronectin conformation regulates the proangiogenic capability of tumor-associated adipogenic stromal cells [J].

Wan, Alwin M. D. ;

Chandler, Emily M. ;

Madhavan, Maya ;

Infanger, David W. ;

Ober, Christopher K. ;

Gourdon, Delphine ;

Malliaras, George G. ;

Fischbach, Claudia .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2013, 1830 (09) :4314-4320

[5] Delayed VEGF Treatment Enhances Angiogenesis and Recovery After Neonatal Focal Rodent Stroke [J].

Dzietko, M. ;

Derugin, N. ;

Wendland, M. F. ;

Vexler, Z. S. ;

Ferriero, D. M. .

TRANSLATIONAL STROKE RESEARCH, 2013, 4 (02) :189-200

[6]

Upregulation of fibronectin and the α5β1 and αvβ3 integrins on blood vessels within the cerebral ischemic penumbra[J] . Longxuan Li,Fudong Liu,Jennifer V. Welser-Alves,Louise D. McCullough,Richard Milner.Experimental Neurology . 2011 (1)

[7] Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents [J].

Lee, Boyeon ;

Clarke, Douglas ;

Al Ahmad, Abraham ;

Kahle, Michael ;

Parham, Christi ;

Auckland, Lisa ;

Shaw, Courtney ;

Fidanboylu, Mehmet ;

Orr, Anthony Wayne ;

Ogunshola, Omolara ;

Fertala, Andrzej ;

Thomas, Sarah A. ;

Bix, Gregory J. .

JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (08) :3005-3023

[8] VEGF Promotes Angiogenesis and Functional Recovery in Stroke Rats [J].

Yang, Ji-Ping ;

Liu, Huai-Jun ;

Liu, Xin-Feng .

JOURNAL OF INVESTIGATIVE SURGERY, 2010, 23 (03) :149-155

[9] Vascular Endothelial Growth Factor Receptor-2 Inhibition Promotes Cell Death and Limits Endothelial Cell Proliferation in a Neonatal Rodent Model of Stroke [J].

Shimotake, Janet ;

Derugin, Nikita ;

Wendland, Michael ;

Vexler, Zinaida S. ;

Ferriero, Donna M. .

STROKE, 2010, 41 (02) :343-349

[10]

In the hypoxic central nervous system, endothelial cell proliferation is followed by astrocyte activation, proliferation, and increased expression of the α6β4 integrin and dystroglycan[J] . LongxuanLi,Jennifer V.Welser,PaulaDore‐Duffy,Gregory J.del Zoppo,Joseph C.Lamanna,RichardMilner.Glia . 2010 (10)

← 1 2 →