鱼藤酮的多巴胺神经元毒性与帕金森病

被引：31

作者：

董兆君

机构：

[1] 休斯顿Baylor医学院神经系 (TX

[2] USA)

来源：

国外医学神经病学神经外科学分册. | 2001年 / 05期

关键词：

鱼藤酮; 多巴胺神经元; 帕金森病;

D O I：

10.16636/j.cnki.jinn.2001.05.016

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

1002 ;

摘要：

野生植物毛鱼藤液汁中含有六种鱼藤酮类化合物 ,其中鱼藤酮毒性最大。鱼藤酮能与线粒体复合物I(complexI)即NADH脱氢酶结合并抑制其活性 ,阻断细胞呼吸链的递氢功能和氧化磷酸化过程 ,从而产生细胞毒作用。近年研究发现 ,长期暴露于鱼藤酮的大鼠中脑DA神经元内出现典型的Lewy小体 ,Flouro -JadeB等多种方法等均证实其DA神经元的退行变性 ,而胆碱能神经系统未受影响。同时 ,鱼藤酮中毒大鼠还出现行动呆滞、僵住症等帕金森病样临床症状。这些结果提示鱼藤酮对中枢DA神经系统有选择性损伤作用。本文结合近年来对帕金森病研究的进展 ,从不同角度分析鱼藤酮与帕金森病的相关性。

引用

页码：357 / 360

页数：4

共 16 条

[1]

Schapira AH,Cooper JM,Dexter D,et al.Mitochondrial complex I deficiency in Parkinson’s disease. Journal of Neurochemistry . 1990

[2]

Friedrich T,Ohnishi T,Forche E,et al.Two binding sites for naturally occurring inhibitors in mitochondrial and bacterial NADH: ubiquinone oxidoreductase (complex I). Biochemical Society Transactions . 1994

[3]

Santiago M,Granero L,Machado A,et al.Complex I inhibitor effect on the nigral and striatal release of dopamine in the presence and absence of nomifensine. European Journal of Pharmacology . 1995

[4]

Kitajima- Ihara T,Yagi T.Rotenone- insensitive internal NADHquinone oxidoreductase of Saccharomyces cerevisiae mitochondria: the enzyme expressed in Escherichia coli acts as a member of the respiratory chain in the host cells. FEBS Letters . 1998

[5]

Zamzami N,Susin SA,Marchetti P,et al.Mitochondrial control of nuclear apoptosis. The Journal of Experimental Medicine . 1996

[6]

Thiffault C,Langston JW,Di Monte DA.Increased striatal dopamine turnover following acute administration of rotenone to mice. Brain Research . 2000

[7]

Duan W,Zhang Z,Gash DM,et al.Participation of prostate apoptosis response- 4 in degeneration of dopaminergic neurons in models of Parkinson’s disease. Annals of Neurology . 1999

[8]

Betarbet R,Sherer TB,MacKenzie G,et al.Chronic systemic pesticide exposure reproduces features of Parkinson’s disease. Nature Neuroscience . 2000

[9]

Seaton TA,Cooper JM,Schapira AH.Free radical scavengers protect dopamine cell lines from apoptosis induced by complex I inhibitors. Brain Research . 1997

[10]

Hollingworth RM,Ahammadsahib KI,Gadelhak G. et al.New inhibitors of complex I of the mitochondrial electron transport chain with activity as pesticides. Biochemical Society Transactions . 1994

← 1 2 →