认知功能障碍药物治疗的研究进展

被引:3
作者
宋莉莉 [1 ]
朱雪红 [1 ]
邵福源 [2 ]
机构
[1] 中国人民解放军第八五医院神经内科
[2] 第二军医大学附属长征医院神经内科
关键词
认知功能障碍; 药物; 治疗;
D O I
暂无
中图分类号
R749.16 [];
学科分类号
100203 ;
摘要
认知功能障碍治疗药物主要通过增强胆碱能神经功能、降低兴奋性氨基酸毒性、抗氧化、抑制β-淀粉样蛋白的生成及激活神经细胞代谢等途径发挥作用。神经变性和血管病变是引起认知功能障碍的两个重要因素。本文对认知功能障碍药物治疗研究进展进行综述。
引用
收藏
页码:562 / 566
页数:5
相关论文
共 12 条
[1]   双益平综合治疗阿尔茨海默病的临床观察 [J].
李宁 ;
刘欣 ;
万争艳 .
中国民康医学, 2008, (09) :912+915-912
[2]   银杏叶提取物对经铝化物诱导的阿尔茨海默病模型大鼠的影响 [J].
肖淑萍 ;
吉中国 .
中国基层医药, 2006, (03) :405-408
[3]   石杉碱甲对体外培养大鼠脊髓片前角运动神经元损伤的保护作用 [J].
刘卫刚 ;
肖向建 ;
李敏 ;
马征 ;
李春岩 .
中国新药与临床杂志, 2005, (12) :933-937
[4]   Donepezil delays progression to AD in MCI subjects with depressive symptoms [J].
Lu, P. H. ;
Edland, S. D. ;
Teng, E. ;
Tingus, K. ;
Petersen, R. C. ;
Cummings, J. L. .
NEUROLOGY, 2009, 72 (24) :2115-2121
[5]   A randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease [J].
Pasqualetti, Patrizio ;
Bonomini, Cristina ;
Dal Forno, Gloria ;
Paulon, Luca ;
Sinforiani, Elena ;
Marra, Camillo ;
Zanetti, Orazio ;
Rossini, Paolo Maria .
AGING CLINICAL AND EXPERIMENTAL RESEARCH, 2009, 21 (02) :102-110
[6]  
Synergistic effects of selegiline and donepezil on cognitive impairment induced by amyloid beta (25–35)[J] . Hiroko Tsunekawa,Yukihiro Noda,Akihiro Mouri,Fumio Yoneda,Toshitaka Nabeshima.Behavioural Brain Research . 2008 (2)
[7]   Donepezil preserves cognition and global function in patients with severe Alzheimer disease [J].
Black, S. E. ;
Doody, R. ;
Li, H. ;
McRae, T. ;
Jambor, K. M. ;
Xu, Y. ;
Sun, Y. ;
Perdomo, C. A. ;
Richardson, S. .
NEUROLOGY, 2007, 69 (05) :459-469
[8]  
Memantine Treatment of Cognitive Symptoms in Mild to Moderate Alzheimer Disease: Secondary Analyses From a Placebo-controlled Randomized Trial[J] . Nunzio Pomara,Brian R. Ott,Elaine Peskind,E. Malca Resnick.Alzheimer Disease & Associated Disorders . 2007 (1)
[9]   Identification of responders and reactive domains to rivastigmine in Alzheimer's disease [J].
Frankfort, S. V. ;
Appels, B. A. ;
de Boer, A. ;
Tulner, L. R. ;
van Campen, J. P. C. M. ;
Koks, C. H. W. ;
Beijnen, J. H. ;
Schmand, B. A. .
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2007, 16 (05) :545-551
[10]  
Cognitive Response to Memantine in Moderate to Severe Alzheimer Disease Patients Already Receiving Donepezil: An Exploratory Reanalysis[J] . Frederick A. Schmitt,Christopher H. van Dyck,Christine H. Wichems,Jason T. Olin.Alzheimer Disease & Associated Disorders . 2006 (4)