基质金属蛋白酶与动脉粥样硬化斑块破裂研究进展

被引：6

作者：

周新福 ^{[1
]}

朱文玲 ^{[2
]}

机构：

[1] 山东威海市立医院心内科

[2] 北京协和医院心内科

来源：

医学综述 | 2008年 / 09期

关键词：

基质金属蛋白酶; 动脉粥样硬化; 斑块破裂;

D O I：

暂无

中图分类号：

R543 [血管疾病];

学科分类号：

1002 ; 100201 ;

摘要：

基质金属蛋白酶(MMPs)是降解细胞外基质最重要的酶类。动脉粥样硬化(AS)的形成是细胞外基质重构的过程,MMPs贯穿于AS发生、发展的全过程。近年来,人们对MMPs与急性冠状动脉综合征(ACS)的发生、发展进行了广泛深入的研究,大量证据表明,MMPs与AS斑块破裂、ACS的发生密切相关,起到了关键性作用。本文综述了MMPs与AS斑块破裂的研究进展。

引用

页码：1305 / 1307

页数：3

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