华法林在心房颤动抗凝治疗中的应用

被引:36
作者
何华
马长生
机构
[1] 首都医科大学附属北京安贞医院心内科
关键词
华法林; 心房颤动; 抗凝治疗;
D O I
暂无
中图分类号
R541.75 [];
学科分类号
1002 ; 100201 ;
摘要
心房颤动(AF)是最常见的持续性心律失常,其主要可能致命的危险就是血栓形成。华法林抗凝治疗可显著减少2/3卒中风险,对瓣膜病和非瓣膜病AF均有效,但存在监测较麻烦、治疗窗窄、有潜在出血危险等不利之处。本文比较了华法林临床应用与其他口服凝血酶抑制剂和Xa因子拮抗剂及抗血小板药物治疗的现状。
引用
收藏
页码:16 / 19
页数:4
相关论文
共 5 条
[1]   Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial [J].
Connolly, S. ;
Pogue, J. ;
Hart, R. ;
Pfeffer, M. ;
Hohnloser, S. ;
Chrolavicius, S. ;
Yusuf, S. .
LANCET, 2006, 367 (9526) :1903-1912
[2]   Culprit factors for the failure of well-conducted warfarin therapy to prevent ischemic events in patients with atrial fibrillation - The role of homocysteine [J].
Poli, D ;
Antonucci, E ;
Cecchi, E ;
Marcucci, R ;
Liotta, AA ;
Cellai, AP ;
Lenti, M ;
Gensini, GF ;
Abbate, R ;
Prisco, D .
STROKE, 2005, 36 (10) :2159-2163
[3]   Gender differences in the risk of ischemic stroke and peripheral embolism in atrial fibrillation - The AnTicoagulation and risk factors in atrial fibrillation (ATRIA) study [J].
Fang, MC ;
Singer, DE ;
Chang, YC ;
Hylek, EM ;
Henault, LE ;
Jensvold, NG ;
Go, AS .
CIRCULATION, 2005, 112 (12) :1687-1691
[4]   Antithrombotic therapy for stroke prevention in atrial fibrillation [J].
Go, AS ;
Fang, MC ;
Singer, DE .
PROGRESS IN CARDIOVASCULAR DISEASES, 2005, 48 (02) :108-124
[5]   Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): randomised controlled trial [J].
Albers, GW ;
Diener, HC ;
Grind, M ;
Halperin, JL ;
Horrow, J ;
Olsson, SB ;
Petersen, P ;
Vahanian, A ;
Frison, L ;
Nevinson, M ;
Partridge, S .
LANCET, 2003, 362 (9397) :1691-1698