新的P2Y12抑制剂在冠状动脉疾病中的应用

被引:2
作者
韩常宝
贾宁
王海玲
机构
[1] 北京军区总院临床部心肾内科
关键词
P2Y12抑制剂; 氯吡格雷; 普拉格雷; 替卡格雷; 依诺格雷;
D O I
暂无
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)];
学科分类号
1002 ; 100201 ;
摘要
在新的P2Y12受体拮抗剂中,普拉格雷对于糖尿病、ST段抬高型心肌梗死、冠状动脉支架、近期心血管事件的抗栓治疗方面优于氯吡格雷;对于ST段抬高型心肌梗死和非ST段抬高型心肌梗死患者预防主要心血管事件的有效性和安全性方面,替卡格雷均优于氯吡格雷;依诺格雷是一种直接作用、可逆性的P2Y12抑制剂,较氯吡格雷有更好的抗血栓作用,且出血发生率同安慰剂。
引用
收藏
页码:1705 / 1708
页数:4
相关论文
共 8 条
[1]  
Ticagrelor: A Novel Reversible Oral Antiplatelet Agent[J] . James J. Nawarskas,Sara M. Clark.Cardiology in Review . 2011 (2)
[2]  
Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials[J] . Michelle L O’Donoghue,Eugene Braunwald,Elliott M Antman,Sabina A Murphy,Eric R Bates,Yoseph Rozenman,Alan D Michelson,Raymond W Hautvast,Peter N Ver Lee,Sandra L Close,Lei Shen,Jessica L Mega,Marc S Sabatine,Stephen D Wiviott.The Lancet . 2009 (9694)
[3]  
Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial[J] . Gilles Montalescot,Stephen D Wiviott,Eugene Braunwald,Sabina A Murphy,C Michael Gibson,Carolyn H McCabe,Elliott M Antman.The Lancet . 2009 (9665)
[4]  
Safety and feasibility of adjunctive antiplatelet therapy with intravenous elinogrel, a direct-acting and reversible P2Y12 ADP-receptor antagonist, before primary percutaneous intervention in patients with ST-elevation myocardial infarction: The Early Rapid ReversAl of Platelet ThromboSis with Intravenous Elinogrel before PCI to Optimize REperfusion in Acute Myocardial Infarction (ERASE MI) pilot trial[J] . Jeffrey S. Berger,Matthew T. Roe,C. Michael Gibson,Rakhi Kilaru,Cynthia L. Green,Laura Me
[5]  
Greater Clinical Benefit of More Intensive Oral Antiplatelet Therapy With Prasugrel in Patients With Diabetes Mellitus in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel–Thrombolysis in Myocardial Infarction 38[J] . Stephen D. Wiviott,Eugene Braunwald,Dominick J. Angiolillo,Simha Meisel,Anthony J. Dalby,Freek W.A. Verheugt,Shaun G. Goodman,Ramon Corbalan,Drew A. Purdy,Sabina A. Murphy,Carolyn H. McCabe,Elliott M. Antman.Circulation . 2008
[6]  
Safety, Tolerability, and Initial Efficacy of AZD6140, the First Reversible Oral Adenosine Diphosphate Receptor Antagonist, Compared With Clopidogrel, in Patients With Non–ST-Segment Elevation Acute Coronary Syndrome[J] . Journal of the American College of Cardiology . 2007 (19)
[7]   Preclinical and clinical studies with selective reversible direct P2Y12 antagonists [J].
van Giezen, JJJ ;
Humphries, RG .
SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2005, 31 (02) :195-204
[8]  
Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently. Farid NA,Payne CD,Small DS,et al. Clinical Pharmacology and Therapeutics . 2007