NF-κB信号通路在脑损伤修复中的作用

被引：3

作者：

杨丽 ^{[1
]}

倪宏 ^{[2
]}

陈溪萍 ^{[1
]}

陶陆阳 ^{[1
,2
]}

机构：

[1] 苏州大学医学院法医学教研室

[2] 苏州大学衰老与神经疾病实验室

来源：

中华神经医学杂志 | 2008年 / 06期

关键词：

脑修复; 核因子-κB; 神经保护;

D O I：

暂无

中图分类号：

R651.1 [颅脑];

学科分类号：

1002 ; 100210 ;

摘要：

<正>核因子NF-κB(nuclear factor-kappa B,NF-κB)在感染和免疫反应及控制细胞分化和凋亡中起着重要的作用,这些作用在神经系统中很明显。神经元及其临近的细胞通过NF-κB通路表达不同的功能,这些功能包括从神经系统损伤后各种细胞的联合反应到像与认知、记忆有关的突触信号等脑的特

引用

页码：642 / 645

共 10 条

[1] NF-kB在神经元变性中的作用 [J].

陶陆阳 ;

陈溪萍 ;

丁梅 ;

官大威 .

中国法医学杂志, 2002, (02) :126-128

[2]

NF-κB functions in the nervous system: From development to disease[J] . Sylvie Mémet.Biochemical Pharmacology . 2006 (9)

[3]

Could NF-κB and caspase-3 be markers for estimation of post-interval of human traumatic brain injury?[J] . Luyang Tao,Xiping Chen,Zhenghong Qin,Shizhong Bian.Forensic Science International . 2006 (1)

[4] Thiopental-induced apoptosis in lymphocytes is independent of CD95 activation [J].

Keel, M ;

Mica, L ;

Stover, J ;

Stocker, R ;

Trentz, O ;

Härter, L .

ANESTHESIOLOGY, 2005, 103 (03) :576-584

[5]

Glutamate promotes NF-κB pathway in primary astrocytes: protective effects of IRFI 016, a synthetic vitamin E analogue[J] . Daniela Caccamo,Agata Campisi,Herbert Marini,Elena B. Adamo,Giovanni Li Volti,Francesco Squadrito,Riccardo Ientile.Experimental Neurology . 2005 (2)

[6]

Neuroprotection by transforming growth factor-β1 involves activation of nuclear factor-κB through phosphatidylinositol-3-OH kinase/Akt and mitogen-activated protein kinase-extracellular-signal regulated kinase1,2 signaling pathways[J] . Y Zhu,C Culmsee,S Klumpp,J Krieglstein.Neuroscience . 2004 (4)

[7] NF-κB activity decreases in basal forebrain of young and aged rats after hyperoxia [J].

Toliver-Kinsky, T ;

Rassin, D ;

Perez-Polo, JR .

NEUROBIOLOGY OF AGING, 2002, 23 (05) :899-905

[8] NF-κB p50 is increased in neurons surviving hippocampal injury [J].

Pennypacker, KR ;

Kassed, CA ;

Eidizadeh, S ;

Saporta, S ;

Sanberg, PR ;

Willing, AE .

EXPERIMENTAL NEUROLOGY, 2001, 172 (02) :307-319

[9] Expression of nuclear factor κB and tumor necrosis factor α in the mouse brain after experimental thermal ablation injury [J].

Nomoto, Y ;

Yamamoto, M ;

Fukushima, T ;

Kimura, H ;

Ohshima, K ;

Tomonaga, M .

NEUROSURGERY, 2001, 48 (01) :158-166

[10]

Contribution of NF- κ B and p53 in the glutamate-induced apoptosis[J] . Daniela Uberti,Mariagrazia Grilli,Maurizio Memo.International Journal of Developmental Neuroscience . 2000 (4)

← 1 →