丹酚酸B对兔离体心脏缺氧再复氧损伤的保护作用

被引：14

作者：

武骏

徐立

许立

机构：

[1] 南京中医药大学药理学教研室

来源：

中国药理学与毒理学杂志 | 2007年 / 03期

关键词：

丹酚酸B; 心肌再灌注损伤; 缺氧; 肌酸激酶; 乳酸脱氢酶;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

1008 ;

摘要：

目的观察丹酚酸B对兔离体心脏缺氧-复氧损伤的保护作用。方法离体兔心脏Langendorff灌流,通氮气饱和的灌流液60min后再恢复含氧灌流液灌流60min,造成缺氧-复氧损伤;自动生化分析仪测定冠脉流出液中肌酸激酶(CK)和乳酸脱氢酶(LDH)活性;光学显微镜观察心肌组织结构改变。结果在缺氧的同时给予丹酚酸B0.3,1和3mg.L-l灌流60min,可降低心率,增加冠脉流量,降低冠脉流出液中CK和LDH的水平,心肌组织形态学损伤明显减轻。结论丹酚酸B对兔离体心脏缺氧-复氧损伤有明显的保护作用。

引用

页码：212 / 216

页数：5

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