高血压左室肥厚机制的研究进展

被引：14

作者：

潘建红 ^{[1
]}

王佩显 ^{[2
]}

机构：

[1] 天津市南开医院心功能科

[2] 天津市总医院心脏科

来源：

重庆医学 | 2015年 / 44卷 / 30期

关键词：

高血压; 左室肥厚; 机制;

D O I：

暂无

中图分类号：

R541.3 [高血压性心脏病];

学科分类号：

1002 ; 100201 ;

摘要：

<正>目前,高血压仍然是一个高发病率、高病死率的重要公共健康问题,严重威胁着人们的生命和健康。左室肥厚(left ventricular hypertrophy,LVH)是高血压靶器官损害最重要的特征之一,是心血管事件独立的危险因素[4],可显著增加心源性猝死(SCD)、急性心肌梗死、心力衰竭、室性心律失常等心血管事件的发生率和病死率,严重影响高血压的预后。1高血压LVH概述

引用

页码：4292 / 4294

页数：3

共 9 条

[1]

ET-1 from endothelial cells is required for complete angiotensin II-induced cardiac fibrosis and hypertrophy[J] . Suko Adiarto,Susi Heiden,Nicolas Vignon-Zellweger,Kazuhiko Nakayama,Keiko Yagi,Masashi Yanagisawa,Noriaki Emoto.Life Sciences . 2012 (13-1)

[2] Cardio-Cerebrovascular Protective Effects of Valsartan in High-Risk Hypertensive Patients With Coronary Artery Disease (from the Kyoto Heart Study) [J].

Shiraishi, Jun ;

Sawada, Takahisa ;

Koide, Masahiro ;

Yamada, Hiroyuki ;

Matsubara, Hiroaki .

AMERICAN JOURNAL OF CARDIOLOGY, 2012, 109 (09) :1308-1314

[3] Interaction Between NFκB and NFAT Coordinates Cardiac Hypertrophy and Pathological Remodeling [J].

Liu, Qinghang ;

Chen, Yi ;

Auger-Messier, Mannix ;

Molkentin, Jeffery D. .

CIRCULATION RESEARCH, 2012, 110 (08) :1077-U138

[4]

Caloric Restriction Ameliorates Angiotensin II–Induced Mitochondrial Remodeling and Cardiac Hypertrophy[J] . Hypertension . 2012 (1)

[5] FGF23 induces left ventricular hypertrophy [J].

Faul, Christian ;

Amaral, Ansel P. ;

Oskouei, Behzad ;

Hu, Ming-Chang ;

Sloan, Alexis ;

Isakova, Tamara ;

Gutierrez, Orlando M. ;

Aguillon-Prada, Robier ;

Lincoln, Joy ;

Hare, Joshua M. ;

Mundel, Peter ;

Morales, Azorides ;

Scialla, Julia ;

Fischer, Michael ;

Soliman, Elsayed Z. ;

Chen, Jing ;

Go, Alan S. ;

Rosas, Sylvia E. ;

Nessel, Lisa ;

Townsend, Raymond R. ;

Feldman, Harold I. ;

Sutton, Martin St. John ;

Ojo, Akinlolu ;

Gadegbeku, Crystal ;

Di Marco, Giovana Seno ;

Reuter, Stefan ;

Kentrup, Dominik ;

Tiemann, Klaus ;

Brand, Marcus ;

Hill, Joseph A. ;

Moe, Orson W. ;

Kuro-o, Makoto ;

Kusek, John W. ;

Keane, Martin G. ;

Wolf, Myles .

JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (11) :4393-4408

[6] The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice [J].

Zhang, Qing-Jun ;

Chen, Hou-Zao ;

Wang, Lin ;

Liu, De-Pei ;

Hill, Joseph A. ;

Liu, Zhi-Ping .

JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (06) :2447-2456

[7] The Progression of Hypertensive Heart Disease [J].

Drazner, Mark H. .

CIRCULATION, 2011, 123 (03) :327-334

[8]

Natriuretic Peptides and the Genomics of Left-Ventricular Hypertrophy[J] . Daniel L. Dries.Heart Failure Clinics . 2010 (1)

[9]

Insulin Signaling: A Possible Pathogenesis of Cardiac Hypertrophy[J] . WeiYu,ChunjuanChen,YucaiFu,XinWang,WeiWang.Cardiovascular Therapeutics . 2010 (2)

← 1 →