清开灵有效组分对大鼠缺血脑组织星形胶质细胞活化的影响

被引：14

作者：

钟相根

李澎涛

王永炎

贾旭

机构：

[1] 北京中医药大学,北京中医药大学,中国中医研究院,北京中医药大学北京,北京,北京,北京

来源：

中国医药学报 | 2004年 / 06期

关键词：

清开灵; 有效组分; 脑缺血; 星形胶质细胞; GFAP; S-100β; 动物实验研究;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

1008 ;

摘要：

目的 :探讨清开灵有效组分对大鼠缺血脑组织星形胶质细胞活化的影响。方法 :参照Longa法复制大鼠脑缺血模型 ,清开灵有效组分干预 ,免疫组化分析缺血脑组织胶质纤维酸性蛋白 (GFAP)、酸性钙结合蛋白 (S 1 0 0 β)表达的组间与时效特征。结果 :脑缺血后GFAP、S 1 0 0 β表达增强。用药可增强缺血 1 2hGFAP、S 1 0 0 β的表达 ,促进星形胶质细胞的激活 ,对受损神经元发挥保护作用 ;至缺血 2 4h ,除珍珠母水解液组外 ,其余用药组促进GFAP、S 1 0 0 β表达的作用减弱。结论 :清开灵有效组分促进星形胶质细胞活化的作用具有明显时效性和相对特异性 ,黄芩苷、栀子苷的作用在于促进星形胶质细胞的反应性增生 ,而胆酸、珍珠母水解液则表现为对星形胶质细胞功能活化的促进作用。

引用

页码：338 / 340

页数：3

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