依达拉奉对大鼠脑缺血再灌注损伤的保护作用

被引：8

作者：

张百权

杨文琼

机构：

[1] 郧阳医学院附属东风医院神经内科

来源：

神经损伤与功能重建 | 2007年 / 05期

关键词：

依达拉奉; 缺血再灌注; 血清超氧化物歧化酶; 丙二醛;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

目的:观察依达拉奉对大鼠脑缺血再灌注损伤的影响,并探讨其可能的作用机制。方法:制备SD大鼠MCAO模型,梗死2h后再灌注,并分为假手术组、生理盐水(NS)组、依达拉奉低剂量组及依达拉奉高剂量组,再灌注24h后进行神经功能缺损评分及检测各组脑组织超氧化物歧化酶(SOD)、丙二醛(MDA)浓度。结果:①依达拉奉低剂量与高剂量组的神经功能缺损评分明显低于NS组(P<0.01),且依达拉奉高济量组的神经功能缺损评分明显低于低剂量组(P<0.01);②与假手术组相比,NS组SOD活性降低、MDA含量增加,有显著性差异(P<0.01);与NS组相比,依达拉奉低剂量与高剂量组SOD活性增高、MDA含量降低(P<0.01),且低剂量组与高剂量组相比有显著性差异(P<0.01)。结论:依达拉奉通过降低自由基水平,对脑缺血再灌注损伤有保护作用。

引用

页码：287 / 288+296 +296

页数：3

共 6 条

[1]

药理实验方法学[M]. 人民卫生出版社 , 徐叔云等主编, 2002

[2]

Short-Term Administration of a New Free Radical Scavenger, Edaravone, Is More Effective Than its Long-Term Administration for the Treatment of Neonatal Hypoxic–Ischemic Encephalopathy[J] . Jesmin I. Noor,Tomoaki Ikeda,Kenichi Mishima,Naoya Aoo,Sumie Ohta,Nobuaki Egashira,Katsunori Iwasaki,Michihiro Fujiwara,Tsuyomu Ikenoue.Stroke . 2005 (11)

[3]

A Radical Scavenger, Edaravone, Protects Canine Kidneys from Ischemia-Reperfusion Injury after 72 Hours of Cold Preservation and Autotransplantation[J] . Munenori Tahara,Masato Nakayama,Maeng B. Jin,Miri Fujita,Tomomi Suzuki,Masahiko Taniguchi,Tsuyoshi Shimamura,Hiroyuki Furukawa,Satoru Todo.Transplantation . 2005 (2)

[4]

Edaravone, a newly developed radical scavenger, protects against ischemia-reperfusioninjury of the small intestine in rats[J] . Naoya Tomatsuri,Norimasa Yoshida,Tomohisa Takagi,Kazuhiro Katada,Yutaka Isozaki,Eiko Imamoto,Kazuhiko Uchiyama,Satoshi Kokura,Hiroshi Ichikawa,Yuji Naito,Takeshi Okanoue,Toshikazu Yoshikawa.International Journal of Molecular Medicine . 2004 (1)

[5] MCI-186 prevents spinal cord damage and affects enzyme levels of nitric oxide synthase and Cu/Zn superoxide dismutase after transient ischemia in rabbits [J].

Takahashi, G ;

Sakurai, M ;

Abe, K ;

Itoyama, Y ;

Tabayashi, K .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2003, 126 (05) :1461-1466

[6] REVERSIBLE MIDDLE CEREBRAL-ARTERY OCCLUSION WITHOUT CRANIECTOMY IN RATS [J].

LONGA, EZ ;

WEINSTEIN, PR ;

CARLSON, S ;

CUMMINS, R .

STROKE, 1989, 20 (01) :84-91

← 1 →