术后认知功能障碍病理生理研究新进展

被引：27

作者：

周汾

李肇端

余剑波

机构：

[1] 天津市南开医院麻醉科

来源：

医学综述 | 2011年 / 17卷 / 07期

关键词：

术后认知功能障碍; 病理生理研究; 防治措施;

D O I：

暂无

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

术后认知功能障碍(POCD)是麻醉手术后较严重的并发症之一,POCD具有多因素的发病机制,而术中全麻药和阿片类药物的应用加之睡眠紊乱患者术后较易发生POCD。另外,外科手术尤其心脏手术介导的炎性反应与POCD密切相关。因此,合理使用各类麻醉药以及减少炎性反应将会减少POCD的发生。在此重点就近年来POCD的发生因素、机制及防治措施进行综述。

引用

页码：1026 / 1029

页数：4

共 18 条

[1] 老年患者术后认知功能障碍的研究进展 [J].

鲍杨 ;

史东平 ;

封卫征 .

中国老年学杂志, 2009, 29 (20) :2689-2692

[2]

Iatrogenic Risk Factors for Alzheimer’s Disease: Surgery andAnesthesia[J] . Pravat K. Mandal,Vincenzo Fodale,Tara Vanderweyde,Martin M. Bednar,Stuart A. Forman,Benjamin Wolozin.Journal of Alzheimer’s Disease . 2010 (s3)

[3] Opioid-induced Decreases in Rat Brain Adenosine Levels Are Reversed by Inhibiting Adenosine Deaminase [J].

Nelson, Ariana M. ;

Battersby, Alanna S. ;

Baghdoyan, Helen A. ;

Lydic, Ralph .

ANESTHESIOLOGY, 2009, 111 (06) :1327-1333

[4]

Opiates, Sleep, and Pain: The Adenosinergic Link[J] . Jason T. Moore,Max B. Kelz.Anesthesiology . 2009 (6)

[5] The Effects of Cardiopulmonary Bypass on the Number of Cerebral Microemboli and the Incidence of Cognitive Dysfunction After Coronary Artery Bypass Graft Surgery [J].

Liu, Ying-Hua ;

Wang, Dong-Xin ;

Li, Li-Huan ;

Wu, Xin-Min ;

Shan, Guo-Jin ;

Su, Yu ;

Li, Jun ;

Yu, Qin-Jun ;

Shi, Chun-Xia ;

Huang, Yi-Ning ;

Sun, Wei .

ANESTHESIA AND ANALGESIA, 2009, 109 (04) :1013-1022

[6]

Drugs with anticholinergic properties: cognitive and neuropsychiatric side-effects in elderly patients[J] . Iacopo Cancelli,Massimiliano Beltrame,Gian Luigi Gigli,Mariarosaria Valente.Neurological Sciences . 2009 (2)

[7] Disturbances in the circadian pattern of activity and sleep after laparoscopic versus open abdominal surgery [J].

Gogenur, Ismail ;

Bisgaard, Thue ;

Burgdorf, Stefan ;

van Someren, Eus ;

Rosenberg, Jacob .

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 2009, 23 (05) :1026-1031

[8] Predictors of cognitive dysfunction after major noncardiac surgery [J].

Monk, Terri G. ;

Weldon, B. Craig ;

Garvan, Cyndi W. ;

Dede, Duane E. ;

van der Aa, Maria T. ;

Heilman, Kenneth M. ;

Gravenstein, Joachim S. .

ANESTHESIOLOGY, 2008, 108 (01) :18-30

[9]

Postoperative Impairment of Cognitive Function in Rats: A Possible Role for Cytokine-mediated Inflammation in the Hippocampus[J] . Yanjie Wan,Jing Xu,Daqing Ma,Yinming Zeng,Mario Cibelli,Mervyn Maze.Anesthesiology . 2007 (3)

[10]

C-reactive protein, but not homocysteine, is related to cognitive dysfunction in older adults with cardiovascular disease[J] . John Gunstad,Linda Bausserman,Robert H. Paul,David F. Tate,Karin Hoth,Athena Poppas,Angela L. Jefferson,Ronald A. Cohen.Journal of Clinical Neuroscience . 2006 (5)

← 1 2 →