尿酸对认知功能的影响

被引：11

作者：

王晓君

罗蔚锋

刘春风

机构：

[1] 苏州大学附属第二医院神经内科

来源：

国际老年医学杂志 | 2010年 / 31卷 / 01期

关键词：

痴呆; 认知功能障碍; 动脉粥样硬化; 氧化应激; 尿酸;

D O I：

暂无

中图分类号：

R749.1 [脑器质性精神障碍];

学科分类号：

100205 ;

摘要：

阿尔茨海默病和帕金森病足老年人常见的神经退行性疾病。认知功能障碍是阿尔茨海默病的主要临床表现,帕金森病在发展过程中,尤其到疾病晚期,可合并有痴呆表现,称帕金森病痴呆。不同的调查研究显示,帕金森病患者中有17%～57%会伴发认知功能障碍。研究影响认知功能的相关因素对于防治阿尔茨海默病,提高帕金森病患者的生活质量具有重要的意义。近年来发现,血尿酸水平与认知功能密切相关。

引用

页码：16 / 20

页数：5

共 11 条

[1] Cerebral Ischemia Mediates the Effect of Serum Uric Acid on Cognitive Function [J].

Vannorsdall, Tracy D. ;

Jinnah, H. A. ;

Gordon, Barry ;

Kraut, Michael ;

Schretlen, David J. .

STROKE, 2008, 39 (12) :3418-3420

[2] Uric acid associates with cognition in Parkinson's disease [J].

Annanmaki, Tua ;

Pessala-Driver, Anniina ;

Hokkanen, Laura ;

Murros, Kari .

PARKINSONISM & RELATED DISORDERS, 2008, 14 (07) :576-578

[3] Serum uric acid and brain ischemia in normal elderly adults [J].

Schretlen, D. J. ;

Inscore, A. B. ;

Vannorsdall, T. D. ;

Kraut, M. ;

Pearlson, G. D. ;

Gordon, B. ;

Jinnah, H. A. .

NEUROLOGY, 2007, 69 (14) :1418-1423

[4] Serum uric acid levels and the risk of Parkinson disease [J].

de Lau, LML ;

Koudstaal, PJ ;

Hofman, A ;

Breteler, MMB .

ANNALS OF NEUROLOGY, 2005, 58 (05) :797-800

[5] Relationship of serum uric acid to measures of endothelial function and atherosclerosis in healthy adults [J].

Erdogan, D ;

Gullu, H ;

Caliskan, M ;

Yildirim, E ;

Bilgi, M ;

Ulus, T ;

Sezgin, N ;

Muderrisoglu, H .

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2005, 59 (11) :1276-1282

[6] Status of endothelial dependent vasodilation in patients with hyperuricemia [J].

Kato, M ;

Hisatome, I ;

Tomikura, Y ;

Kotani, K ;

Kinugawa, T ;

Ogino, K ;

Ishida, K ;

Igawa, O ;

Shigemasa, C ;

Somers, VK .

AMERICAN JOURNAL OF CARDIOLOGY, 2005, 96 (11) :1576-1578

[7]

Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease[J] . John Kanellis,Duk-Hee Kang.Seminars in Nephrology . 2005 (1)

[8] Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease [J].

Rinaldi, P ;

Polidori, MC ;

Metastasio, A ;

Mariani, E ;

Mattioli, R ;

Cherubini, A ;

Catani, M ;

Cecchetti, R ;

Senin, U ;

Mecocci, P .

NEUROBIOLOGY OF AGING, 2003, 24 (07) :915-919

[9]

Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study[J] . Albert Hofman,Alewijn Ott,Monique MB Breteler,Michiel L Bots,Arjen JC Slooter,Frans van Harskamp,Cornelia N van Duijn,Christine Van Broeckhoven,Diederick E Grobbee.The Lancet . 1997 (9046)

[10] NEURONAL DAMAGE AND DECREASE OF CENTRAL ACETYLCHOLINE LEVEL FOLLOWING PERMANENT OCCLUSION OF BILATERAL COMMON CAROTID ARTERIES IN RAT [J].

NI, JW ;

MATSUMOTO, K ;

LI, HB ;

MURAKAMI, Y ;

WATANABE, H .

BRAIN RESEARCH, 1995, 673 (02) :290-296

← 1 2 →