microRNA-155在脑卒中发病机制中的研究进展

被引：8

作者：

彭尧群 ^{[1
]}

李友 ^{[2
]}

钟望涛 ^{[3
]}

机构：

[1] 广东医科大学研究生学院

[2] 广东医科大学附属医院神经病学研究所

[3] 广东医科大学附属医院神经内科一区

来源：

广东医学 | 2018年 / 39卷 / 10期

关键词：

miR-155; 脑卒中; 免疫炎症; 动脉粥样硬化; 高血压;

D O I：

10.13820/j.cnki.gdyx.20180611.001

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

脑卒中是世界上发病率、死亡率和致残率最高的疾病之一。microRNAs是一类小分子非编码RNA,它在转录后水平调节靶基因的表达。miR-155在血管免疫炎症、血脑屏障、高血压及动脉粥样硬化等方面有重要的调控作用,这也是脑卒中发病的病理生理基础,而且miR-155在缺血性脑卒中小鼠模型中的表达水平也有着显著的变化。本文将总结探讨miR-155在脑卒中发病机制方面的研究及其作用,探究其可能作为缺血性脑卒中潜在的分子标记及治疗靶标。

引用

页码：1431 / 1434

页数：4

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