阿魏酸衍生物的合成及抗血小板聚集活性

被引:51
作者
李家明
赵永海
钟国琛
龙子江
周鹏
袁明
机构
[1] 安徽中医学院药学院安徽省现代中药重点实验室
关键词
阿魏酸; 阿魏酸衍生物; 血栓; 抗血小板聚集;
D O I
10.16438/j.0513-4870.2011.03.004
中图分类号
R284.1 [化学分析与鉴定]; R285 [中药药理学];
学科分类号
1008 ;
摘要
以具有活血化瘀作用的中药有效成分阿魏酸为先导物,设计合成了6个阿魏酸衍生物,其结构经IR、1H NMR、13C NMR及MS确证。体内药效筛选结果显示,阿魏酸衍生物对二磷酸腺苷(ADP)诱导的血小板聚集具有较好的抑制活性,其抑制作用明显强于阳性对照药奥扎格雷钠。
引用
收藏
页码:305 / 310
页数:6
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