新生鼠脑缺血再灌注后海马CA1区突触素的表达及意义

被引：10

作者：

宋文秀

曹云涛

刘华庆

机构：

[1] 珠海市斗门区遵义医学院第五附属医院儿科

[2] 遵义医学院附属医院儿科

[3] 遵义医学院附属医院病理科广东珠海

[4] 贵州遵义

来源：

第四军医大学学报 | 2004年 / 16期

关键词：

脑缺血; 突触膜糖蛋白; 海马CA1区; 大鼠,Wistar; 动物,新生;

D O I：

暂无

中图分类号：

R722.1 [新生儿疾病];

学科分类号：

100202 ;

摘要：

目的 :观察新生Wistar大鼠脑缺血再灌注后海马CA1区突触素的表达 .探讨中枢神经系统的可塑性 .方法 :应用免疫组化方法观察新生鼠脑缺血再灌注后不同时点脑组织突触素的表达 .结果 :缺血再灌注 3d突触素表达开始增高 ,7d达高峰 ,1 4d时免疫活性仍高 ,其矫正吸光度值与对照组比较有显著性差异 (P <0 .0 1 ) .结论 :新生Wistar大鼠脑神经细胞损伤后具有修复的可塑性 ,其时间持续至缺血再灌注后 1 4d .突触素检测能较好地反映神经元和轴突的代偿再生情况

引用

页码：1467 / 1469

页数：3

共 8 条

[1]

Changes of immunoreactivity for synaptophysin following a transient cerebral ischemia in the rat striatum. Kojiro K,Statoshi G,Shinji N,et al. Brain Research . 1993

[2]

Decreased synaptic density in aged brains and its prevention by rearing under enriched environment as revealed by synaptophysin contents. Saito S,Kobayashi S,Ohashi Y,et al. Neurosciences Research . 1994

[3]

Quantitation of nerve terminal population: Synaptic vesicle-associated proteins as markers for synaptic density in the rat neostriatum. Walaas SI,Jahn R,Greengard P. Synapse . 1988

[4]

Serotoninstimulatesphos phorylationofAplysiasynapsinandaltersitssubcellulardistributioninsensoryneurons.. AngersA,FioravanteD,ChinJ,etal. Neuroscience . 2002

[5]

Identificationandlocalizationofsynaptophysin,anintegralmembraneglycoproteinofMr38,000characteristicofpresynapticvesicles. WiedenmannB ,,FrankeWW. Cell . 1985

[6]

Changes in presynaptic proteins, SNAP-25 and synaptophysin, in the hippocampal CA1 area in ischemic gerbils. Ishimaru H,Casamenti F,Ueda K,et al. Brain Research . 2001

[7]

MAP2, synaptophysin immunostaining in rat brain and behavioral modifications after cerebral postischemic reperfusion. Martinez G,Di Giacomo C,Carnazza ML,et al. Developmental Neuroscience . 1997

[8]

A protein kinase A-dependent molecular switch in synapsins regulates neurite outgrowth. Kao HT,Song HJ,Porton B,et al. National Neuroscience . 2002

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