冠心病患者择期冠状动脉介入治疗术前口服大剂量阿托伐他汀预防对比剂肾病

被引：10

作者：

华先平

吴瑞霞

杨勇

曹政

陈彬

机构：

[1] 湖北医药学院附属太和医院心内科

来源：

华南国防医学杂志 | 2010年 / 24卷 / 06期

关键词：

对比剂肾病; 阿托伐他汀; 冠心病; 冠状动脉介入治疗;

D O I：

10.13730/j.1009-2595.2010.06.005

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

目的了解冠心病患者择期冠状动脉介入治疗(percutaneous coronary intervention,PCI)术前服用大剂量阿托伐他汀对血清高敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)及肾功能的影响。方法选择冠心病择期冠状动脉造影检查需要PCI治疗的患者173例,随机分为大剂量阿托伐他汀组(AS组,n=76)和常规治疗组(C组,n=97),治疗7天后行PCI术。术前和术后检测血清hs-CRP、血清肌酐(serum creatinine,SCr),计算肾小球滤过率(glo-merular filtration rate,GFR)。结果两组患者术前24h血hs-CRP水平,低于入院时(t=2.413和2.309,P<0.05)和术后48h(t=2.087和2.368,P<0.05);AS组PCI术前24h和术后48h血清hs-CRP均低于C组(t=2.007和2.275,P<0.05)。两组PCI术后SCr较术前升高(t=2.464和2.392,P<0.05),GFR较术前降低(t=2.496和2.573,P<0.05);术后AS组SCr低于C组(t=2.337,P<0.05),GFR高于C组(t=2.145,P<0.05)。AS组对比剂肾病(contrast-induced nephropathy,CIN)发生率低于C组(6.58%vs16.49%,χ2=3.93,P<0.05)。结论冠心病择期PCI患者术前服用大剂量阿托伐他汀对CIN可能有良好的预防作用,机制可能与显著抑制炎症反应有关。

引用

页码：448 / 451

页数：4

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