曲美他嗪对慢性心力衰竭患者心功能及心率变异性的影响

被引：6

作者：

庄德荣

蔡定华

朱乃训

王文苑

王璇

机构：

[1] 江苏省扬州市江都人民医院心内科

来源：

中国现代医药杂志 | 2012年 / 14卷 / 06期

关键词：

慢性心力衰竭; 心率变异性; 曲美他嗪;

D O I：

暂无

中图分类号：

R541.6 [血液循环衰竭];

学科分类号：

1002 ; 100201 ;

摘要：

目的探讨曲美他嗪对慢性心力衰竭(CHF)患者心功能及心率变异性(HRV)的影响。方法将60例CHF患者随机分为治疗组和对照组,每组30例,对照组给予常规治疗,治疗组在常规治疗的基础上加用曲美他嗪治疗6个月,观察两组患者治疗前后NYHA分级、左心室舒张末期内径(LVEDd)、左心室射血分数(LVEF)、N末端原脑利钠肽(NT-pro-BNP)及6min步行距离(6-MWD)的变化,采用12导联同步HOLTER检测系统检查,测定HRV时域指标(SDNN、SDANNindex、rMSDD、PNN50)。结果 6个月后,治疗组患者的心功能明显改善,LVEDd及NT-pro-BNP与对照组相比明显降低,LVEF及6-MWD与对照组相比明显增加,HRV参数明显好转。结论曲美他嗪可以改善CHF患者的心功能及HRV。

引用

页码：30 / 33

页数：4

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