步行试验评价阿托伐他汀钙改善心功能衰竭转归初步观察

被引：6

作者：

乔延国 ^{[1
]}

黄志刚 ^{[2
]}

梁立武 ^{[1
]}

机构：

[1] 武警总医院干一科

[2] 解放军医院内科

来源：

实用医学杂志 | 2009年 / 25卷 / 07期

关键词：

心力衰竭,充血性; 6分钟步行试验; 阿托伐他汀钙; 心脏利钠肽; 运动耐量;

D O I：

暂无

中图分类号：

R541.6 [血液循环衰竭];

学科分类号：

1002 ; 100201 ;

摘要：

目的:以6min步行试验评价阿托伐他汀钙治疗慢性充血性心力衰竭(CHF)患者后血浆脑利钠肽(BNP)水平的动态变化,探讨阿托伐他汀钙对患者运动耐量及心脏内分泌的病理生理影响。方法:随机入选116例扩张性心肌病伴CHF患者,其中阿托伐他汀钙组59例,另57例为对照组。Bittner方案行6min步行试验。放射免疫法测定BNP。结果:阿托伐他汀钙治疗6个月后,患者症状、运动耐量明显改善,同时血浆BNP水平明显降低。结论:CHF患者接受阿托伐他汀钙治疗后能缓解心衰症状、提高运动耐量,而且显著改善心脏内分泌功能,这种心脏内分泌变化可能有助于心衰预后。

引用

页码：1130 / 1132

页数：3

共 5 条

[1] Effects of statin therapy on arrhythmic events and survival in patients with nonischemic dilated cardiomyopathy [J].

Goldberger, Jeffrey J. ;

Subacius, Haris ;

Schaechter, Andi ;

Howard, Adam ;

Berger, Ronald ;

Shalaby, Alaa ;

Levine, Joseph ;

Kadish, Alan H. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 48 (06) :1228-1233

[2] Atorvastatin improves left ventricular systolic function and serum markers of inflammation in nonischemic heart failure [J].

Sola, S ;

Mir, MQS ;

Lerakis, S ;

Tandon, N ;

Khan, BV .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 47 (02) :332-337

[3] The effects of Atorvastatin (10 mg) on systemic inflammation in heart failure [J].

Mozaffarian, D ;

Minami, E ;

Letterer, RA ;

Lawler, RL ;

McDonald, GB ;

Levy, WC .

AMERICAN JOURNAL OF CARDIOLOGY, 2005, 96 (12) :1699-1704

[4]

Plasma brain natriuretic peptide as a novel therapeutic indicator in idiopathic dilated cardiomyopathy during β-blocker therapy: A potential of hormone-guided treatment[J] . Keisuke Kawai,Katsuya Hata,Hideyuki Takaoka,Hiroya Kawai,Mitsuhiro Yokoyama.American Heart Journal . 2001 (6)

[5] Prognostic evaluation of neurohumoral plasma levels before and during beta-blocker therapy in advanced left ventricular dysfunction [J].

Stanek, B ;

Frey, B ;

Hülsmann, M ;

Berger, R ;

Sturm, B ;

Strametz-Juranek, J ;

Bergler-Klein, J ;

Moser, P ;

Bojic, A ;

Hartter, E ;

Pacher, R .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 38 (02) :436-442

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