亚甲基四氢叶酸还原酶C677T基因多态性与老年H型高血压并急性心肌梗死的关系

被引:10
作者
曹正余
机构
[1] 云南省第一人民医院急诊内科
关键词
H型高血压; 心肌梗死; 基因; 多态性; 单核苷酸;
D O I
暂无
中图分类号
R544.1 [高血压]; R542.22 [];
学科分类号
1002 ; 100201 ;
摘要
目的探讨亚甲基四氢叶酸还原酶(MTHFR)C677T基因多态性与老年H型高血压并急性心肌梗死(AMI)的关系。方法选择心梗AMI合并H型高血压患者111例,单纯AMI患者110例,单纯H型高血压患者112例和健康体检者148例,采用PCR-RFLP法进行基因多态性检测,高效液相色谱化学法检测血浆总同型半胱氨酸(tHcy)浓度,并检测血液生化指标等,比较分析各组基因多态性和Hcy水平差异。结果 AMI合并H型高血压组与对照组相比,基因分布与差异有统计学意义(P=0.048)。多因素回归分析结果显示TT基因型是AMI合并H型高血压和单纯H型高血压患病的独立危险因素,OR(95%CI)分别为1.38(1.05~1.79)和1.28(1.05~1.58)。结论 MTHFR C677T基因多态性是老年H型高血压并发AMI的独立危险因素,提示应加强针对老年H型高血压人群的冠心病一、二级预防。
引用
收藏
页码:5118 / 5120
页数:3
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