PPAR激动剂治疗中枢神经系统疾病的研究进展

被引：3

作者：

勾海燕

朱雨岚

机构：

[1] 哈尔滨医科大学附属第二临床医学院神经内科

来源：

国际免疫学杂志 | 2013年 / 02期

关键词：

PPAR激动剂; 中枢神经系统疾病;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

1002 ;

摘要：

过氧化物酶增殖体激活受体(PPAR)是一类调节免疫及炎症反应的核转录因子超家族成员。PPAR-α,PPAR-β/δ和PPAR-γ激动剂已被证实在多发性硬化,阿尔兹海默病,帕金森病和脑卒中动物模型中起到抗炎及神经保护作用。PPAR激动剂通过抑制NF-κB,Jak-STAT信号途径的激活及炎症细胞因子的分泌在中枢神经系统疾病的治疗中发挥关键作用。

引用

页码：126 / 131

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