他汀类药物对糖尿病的非降脂作用及机制

被引：13

作者：

陈致瑜

申竹芳

机构：

[1] 中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室

来源：

中国新药杂志 | 2011年 / 20卷 / 21期

关键词：

他汀类药物; 糖尿病; 胰岛素敏感性; 胰岛β细胞; 糖尿病并发症; 抗炎;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

他汀类药物是胆固醇合成的限速酶3羟基-3甲基戊二酰辅酶A的抑制剂。由于胆固醇堆积与动脉粥样硬化等心血管疾病紧密相关,而2型糖尿病患者也常伴有高胆固醇血症,因此他汀类药物被作为冠心病二级预防和改善糖尿病脂质紊乱的一线用药。近年的临床和基础研究证明,他汀类药物除了降脂作用外,还有改善胰岛素敏感性、胰岛β细胞功能和糖代谢,减轻糖尿病并发症和炎症的作用。也有不少相关不良反应的报道,但作用机制尚不明了。研究和探讨他汀类药物在糖尿病防治中的降脂外作用和机制,将有利于这类药物的合理应用。文中主要介绍他汀类药物对糖尿病的非降脂作用及可能机制。

引用

页码：2106 / 2110+2122 +2122

页数：6

共 8 条

[1] Effect of Simvastatin and Fenofibrate on Cytokine Release and Systemic Inflammation in Type 2 Diabetes Mellitus With Mixed Dyslipidemia [J].

Krysiak, Robert ;

Gdula-Dymek, Anna ;

Okopien, Boguslaw .

AMERICAN JOURNAL OF CARDIOLOGY, 2011, 107 (07) :1010-1018

[2] Pleiotropic Effects of Atorvastatin and Fenofibrate in Metabolic Syndrome and Different Types of Pre-Diabetes [J].

Krysiak, Robert ;

Gdula-Dymek, Anna ;

Bachowski, Ryszard ;

Okopien, Boguslaw .

DIABETES CARE, 2010, 33 (10) :2266-2270

[3] Beneficial direct adipotropic actions of pitavastatin in vitro and their manifestations in obese mice [J].

Ishihara, Yasuhiro ;

Ohmori, Koji ;

Mizukawa, Mizuki ;

Hasan, Arif Ul. ;

Noma, Takahisa ;

Kohno, Masakazu .

ATHEROSCLEROSIS, 2010, 212 (01) :131-138

[4]

Improvement of Retinal Vascular Injury in Diabetic Rats by Statins Is Associated With the Inhibition of Mitochondrial Reactive Oxygen Species Pathway Mediated by Peroxisome Proliferator-Activated Receptor[gamma] Coactivator 1[alpha][J] . Zheng, Zhi,Chen, Haibing,Wang, Hong,Ke, Bilian,Zheng, Bingqing,Li, Qian,Li, Peiyu,Su, Li,Gu, Qing,Xu, Xun.Diabetes . 2010 (9)

[5] The HMG-CoA Reductase Inhibitor Pravastatin Stimulates Insulin Secretion through Organic Anion Transporter Polypeptides [J].

Abe, Michiaki ;

Toyohara, Takafumi ;

Ishii, Akiko ;

Suzuki, Takehiro ;

Noguchi, Naoya ;

Akiyama, Yasutoshi ;

Shiwaku, Hiromi O. ;

Nakagomi-Hagihara, Rie ;

Zheng, Guodong ;

Shibata, Eisuke ;

Souma, Tomokazu ;

Shindo, Tomohiko ;

Shima, Hirohito ;

Takeuchi, Yoichi ;

Mishima, Eikan ;

Tanemoto, Masayuki ;

Terasaki, Tetsuya ;

Onogawa, Tohru ;

Unno, Michiaki ;

Ito, Sadayoshi ;

Takasawa, Shin ;

Abe, Takaaki .

DRUG METABOLISM AND PHARMACOKINETICS, 2010, 25 (03) :274-282

[6]

Effect of long‐ and short‐term treatments with pravastatin on diabetes mellitus and pancreatic fibrosis in the Otsuka–Long–Evans–Tokushima Fatty rat[J] . MOtani,MYamamoto,MHarada,MOtsuki.British Journal of Pharmacology . 2010 (2)

[7] Statin modulates insulin signaling and insulin resistance in liver and muscle of rats fed a high-fat diet [J].

Lalli, Cristina Alba ;

Pauli, Jose Rodrigo ;

Prada, Patricia Oliveira ;

Cintra, Dennys Esper ;

Ropelle, Eduardo Rochette ;

Velloso, Licio Augusto ;

Saad, Mario Jose Abdalla .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2008, 57 (01) :57-65

[8] Diabetes [P].

英国专利 :GB201117172D0 ,2011-11-16

← 1 →