解读有关尼莫地平治疗血管性认知功能损害的临床试验

被引:16
作者
李焰生
机构
[1] 上海交通大学医学院附属仁济医院神经科
关键词
尼莫地平; 临床试验;
D O I
暂无
中图分类号
R749.1 [脑器质性精神障碍];
学科分类号
100205 ;
摘要
<正>迄今为止,已有十余种药物治疗血管性痴呆(VaD)的临床研究报道,绝大多数的试验结果令人失望,仅部分试验结果提示治疗能在一定程度上改善受试者的整体功能、认知能力或日常生活能力(ADL)。导致这种现象的原因很多,有些现在还不为我们所知,但试验设计的缺陷及VaD本身的明显异质性被认为是重要的原因[1-3]。因此,必须从两方面予以纠正:第一,应选择恰当的患者人群,不考虑病因、发病机制、病理改变和临床表现的巨大
引用
收藏
页码:549 / 550
页数:2
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