氯吡格雷抵抗及其对策

被引:9
作者
黄震华
机构
[1] 上海交通大学医学院附属第九人民医院心血管病研究室
关键词
血小板聚集; 腺苷二磷酸; 氯吡格雷; 抵抗; 对策;
D O I
暂无
中图分类号
R972 [心血管系统药物];
学科分类号
1007 ;
摘要
氯吡格雷在急性冠脉综合征和经皮冠状动脉介入治疗前后发挥重要作用。氯吡格雷是血小板膜上P2Y12受体的拮抗药。氯吡格雷抵抗包括对氯吡格雷无反应和对氯吡格雷低反应。氯吡格雷抵抗者血小板聚集率高,易发生心血管事件。本文对氯吡格雷的作用机制、氯吡格雷抵抗原因及治疗对策等作一综述。
引用
收藏
页码:616 / 620
页数:5
相关论文
共 6 条
[1]  
Variability in Individual Responsiveness to Clopidogrel[J] . Dominick J. Angiolillo,Antonio Fernandez-Ortiz,Esther Bernardo,Fernando Alfonso,Carlos Macaya,Theodore A. Bass,Marco A. Costa.Journal of the American College of Cardiology . 2007 (14)
[2]  
Randomized Comparison of a High Clopidogrel Maintenance Dose in Patients With Diabetes Mellitus and Coronary Artery Disease: Results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) Study[J] . Dominick J. Angiolillo,Steven B. Shoemaker,Bhaloo Desai,Hang Yuan,Ronald K. Charlton,Esther Bernardo,Martin M. Zenni,Luis A. Guzman,Theodore A. Bass,Marco A. Costa.Circulation . 2007 (6)
[3]  
Initial experience with an intravenous P2Y 12 platelet receptor antagonist in patients undergoing percutaneous coronary intervention: Results from a 2-part, phase II, multicenter, randomized, placebo- and active-controlled trial[J] . Adam B. Greenbaum,Cindy L. Grines,John A. Bittl,Richard C. Becker,Dean J. Kereiakes,Ian C. Gilchrist,Jane Clegg,Jill E. Stankowski,Donna R. Grogan,Robert A. Harrington,Hakan Emanuelsson,W. Douglas Weaver.American Heart Journal . 2006 (3)
[4]   Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment [J].
Angiolillo, Dominick J. ;
Bernardo, Esther ;
Ramirez, Celia ;
Costa, Marco A. ;
Sabate, Manel ;
Jimenez-Quevedo, Pilar ;
Hernandez, Rosana ;
Moreno, Raul ;
Escaned, Javier ;
Alfonso, Fernando ;
Banuelos, Camino ;
Bass, Theodore A. ;
Macaya, Carlos ;
Fernandez-Ortiz, Antonio .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 48 (02) :298-304
[5]   Preclinical and clinical studies with selective reversible direct P2Y12 antagonists [J].
van Giezen, JJJ ;
Humphries, RG .
SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2005, 31 (02) :195-204
[6]  
Randomized Trial of High Loading Dose of Clopidogrel for Reduction of Periprocedural Myocardial Infarction in Patients Undergoing Coronary Intervention: Results From the ARMYDA-2 (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty) Study[J] . Giuseppe Patti,Giuseppe Colonna,Vincenzo Pasceri,Leonardo Lassandro Pepe,Antonio Montinaro,Germano Di Sciascio.Circulation . 2005 (16)