氯吡格雷反应性差异的分子机制研究进展

Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study[J] . Jean-Philippe Collet,Jean-Sébastien Hulot,Anna Pena,Eric Villard,Jean-Baptiste Esteve,Johanne Silvain,Laurent Payot,Delphine Brugier,Guillaume Cayla,Farzin Beygui,Gilbert Bensimon,Christian Funck-Brentano,Gilles Montalescot.The Lancet . 2009 (9660)

Intensifying Platelet Inhibition With Tirofiban in Poor Responders to Aspirin, Clopidogrel, or Both Agents Undergoing Elective Coronary Intervention: Results From the Double-Blind, Prospective, Randomized Tailoring Treatment With Tirofiban in Patients Showing Resistance to Aspirin and/or Resistance to Clopidogrel Study[J] . Marco Valgimigli,Gianluca Campo,Nicoletta de Cesare,Emanuele Meliga,Pascal Vranckx,Alessandro Furgieri,Dominick J. Angiolillo,Manel Sabatè,Martial Hamon,Alessandra Repetto,Sa

Frequency of CYP3A4, CYP3A5, CYP2C9 , and CYP2C19 variant alleles in patients receiving clopidogrel that experience repeat acute coronary syndrome[J] . Marcia L. Brackbill,Robert S. Kidd,April D. Abdoo,James G. Warner,Arthur F. Harralson.Heart and Vessels . 2009 (2)

Cytochrome P450 2C19 681G＞A Polymorphism and High On-Clopidogrel Platelet Reactivity Associated With Adverse 1-Year Clinical Outcome of Elective Percutaneous Coronary Intervention With Drug-Eluting or Bare-Metal Stents[J] . Dietmar Trenk,Willibald Hochholzer,Martin F. Fromm,Ligia-Emilia Chialda,Andreas Pahl,Christian M. Valina,Christian Stratz,Peter Schmiebusch,Hans-Peter Bestehorn,Heinz Joachim Büttner,Franz-Josef Neumann.Journal of the American College of Cardiology . 2008 (20)

Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10+12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients[J] . Betti Giusti,Anna Maria Gori,Rossella Marcucci,Claudia Saracini,Ilaria Sestini,Rita Paniccia,Serafina Valente,Davide Antoniucci,Rosanna Abbate,Gian Franco Gensini.Pharmacogenetics and Genomics . 2007 (12)

Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study[J] . Jean-Philippe Collet,Jean-Sébastien Hulot,Anna Pena,Eric Villard,Jean-Baptiste Esteve,Johanne Silvain,Laurent Payot,Delphine Brugier,Guillaume Cayla,Farzin Beygui,Gilbert Bensimon,Christian Funck-Brentano,Gilles Montalescot.The Lancet . 2009 (9660)

Intensifying Platelet Inhibition With Tirofiban in Poor Responders to Aspirin, Clopidogrel, or Both Agents Undergoing Elective Coronary Intervention: Results From the Double-Blind, Prospective, Randomized Tailoring Treatment With Tirofiban in Patients Showing Resistance to Aspirin and/or Resistance to Clopidogrel Study[J] . Marco Valgimigli,Gianluca Campo,Nicoletta de Cesare,Emanuele Meliga,Pascal Vranckx,Alessandro Furgieri,Dominick J. Angiolillo,Manel Sabatè,Martial Hamon,Alessandra Repetto,Sa

Frequency of CYP3A4, CYP3A5, CYP2C9 , and CYP2C19 variant alleles in patients receiving clopidogrel that experience repeat acute coronary syndrome[J] . Marcia L. Brackbill,Robert S. Kidd,April D. Abdoo,James G. Warner,Arthur F. Harralson.Heart and Vessels . 2009 (2)

Cytochrome P450 2C19 681G＞A Polymorphism and High On-Clopidogrel Platelet Reactivity Associated With Adverse 1-Year Clinical Outcome of Elective Percutaneous Coronary Intervention With Drug-Eluting or Bare-Metal Stents[J] . Dietmar Trenk,Willibald Hochholzer,Martin F. Fromm,Ligia-Emilia Chialda,Andreas Pahl,Christian M. Valina,Christian Stratz,Peter Schmiebusch,Hans-Peter Bestehorn,Heinz Joachim Büttner,Franz-Josef Neumann.Journal of the American College of Cardiology . 2008 (20)

Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10+12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients[J] . Betti Giusti,Anna Maria Gori,Rossella Marcucci,Claudia Saracini,Ilaria Sestini,Rita Paniccia,Serafina Valente,Davide Antoniucci,Rosanna Abbate,Gian Franco Gensini.Pharmacogenetics and Genomics . 2007 (12)