血小板激活因子对大鼠海马脑片CA1区LTP的作用

被引：2

作者：

董军

陆大祥

颜亮

张穗梅

机构：

[1] 暨南大学医学院病理生理教研室,暨南大学医学院病理生理教研室,暨南大学医学院病理生理教研室,暨南大学医学院病理生理教研室广东广州,广东广州,广东广州,广东广州

来源：

中国应用生理学杂志 | 2005年 / 02期

基金：

广东省自然科学基金;

关键词：

HIV-1; PAF; LTP; 海马脑片;

D O I：

10.13459/j.cnki.cjap.2005.02.004

中图分类号：

R363 [病理生理学];

学科分类号：

100104 ;

摘要：

目的:为了探讨血小板激活因子(platelet activatingfactor,PAF)对大鼠海马脑片CA1区的长时程增强效应(long termpotentiation,LTP)的影响。方法:应用离体脑片电生理记录技术,记录大鼠海马CA1区的兴奋性突触后电位EPSP,研究了PAF对大鼠海马脑片CA1区的突触传递和可塑性的影响。结果:小剂量(1μmol/L)PAF可诱发大鼠海马CA1区LTP的产生;大剂量(10～50μmol/L)PAF不能诱发大鼠海马CA1区LTP的产生,且不能阻止高频电刺激(HFS,100Hz,1000ms×2,每隔20s给予)Schaffer侧支引起的大鼠海马脑片CA1区LTP的形成和维持。大剂量PAF对海马CA1区基础EPSP没有影响。PAF受体拮抗剂银杏苦内酯(ginkgolideB,GB)可拮抗小剂量PAF诱发大鼠海马CA1区LTP的产生。结论:大剂量PAF具有神经毒性,可能是通过抑制海马CA1区的LTP的形成而参与艾滋病痴呆(HIV1associateddementia,HAD)的形成机制。

引用

页码：133 / 136

页数：4

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