中国妇女妊娠前后单纯服用叶酸对神经管畸形的预防效果

被引：179

作者：

李竹

RobertJ Berry

李松

J David Erickson

王红

Cynthia A Moore

赵平

Joseph Mulinare

洪世欣

LeeYangCWong

呼和牧人

Jacqueline Gindler

郝玲

Adolfo Correa

朱慧萍

Elaine Gunter

机构：

[1] 北京医科大学中国妇婴保健中心、保健流行病学研究室,NationalCentersforEnvironmentalHealth!CentersforDiseaseControlandPrevention,CDC,北京医科大学中国妇婴保健中心、保健流行病学研究室,NationalCentersforEnvironmentalHealth!CentersforDiseaseControlandPrevention,C

来源：

中华医学杂志 | 2000年 / 07期

关键词：

妊娠; 叶酸; 神经管缺损;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

目的　评价妇女在妊娠前后服用单纯 40 0 μg叶酸增补剂对胎 /婴儿神经管畸形 (NTDs)的预防效果。方法　 1993～ 1995年在中国北方的NTDs高发地区和南方的NTDs低发地区妇女增补叶酸的推广项目中 ,共募集从孕前或孕后任何时间开始服药的妇女 130 142名 ,未服药的妇女 1176 89名 ;设计的服药方法从婚检时开始到孕满 3个月为止 ,每天服用单纯叶酸片 40 0 μg ;最后对妇女的分娩结局进行监测并进行预防效果的对比评价研究。结果　服药组妇女生育的胎婴儿中共发现 10 2例NTDs ,对照组胎婴儿中共发现 173例NTDs。末次月经前募集的未服药妇女在孕 2 0周以后分娩的胎婴中NTDs发生率 ,北方为 4 8‰ (16 / 3 318) ,南方为 1 0‰ (2 8/ 2 82 6 5 ) ,而妊娠前后服药妇女组则分别为1 0‰ (13/ 13 0 12 )和 0 6‰ (34/ 5 86 38)。与末次月经前募集的未服药妇女组相比 ,北方服药妇女NTDs发生率明显降低 ,其中依从性大于 80 %的服药组妇女预防率达 85 % (95 %CI为 6 2 %～ 94% ) ,南方地区服叶酸的预防率为 41% (95 %CI为 3 %～ 6 4% )。结论　妇女在妊娠前后每天服用单纯叶酸 40 0 μg在NTDs的高发地区和低发地区均能降低NTDs发生的危险性

引用

页码：9 / 14

页数：6

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