抑郁症患者认知功能障碍与血浆脑源性神经营养因子水平的关系

被引：8

作者：

冯玉 ^{[1
]}

戴媛媛 ^{[1
]}

杨志寅 ^{[2
]}

吉峰 ^{[2
]}

机构：

[1] 新乡, 新乡医学院

[2] 济宁医学院

来源：

中华行为医学与脑科学杂志 | 2013年 / 22卷 / 08期

关键词：

抑郁症; 认知障碍; 脑源性神经营养因子;

D O I：

暂无

中图分类号：

R749.1 [脑器质性精神障碍];

学科分类号：

100205 ;

摘要：

目的探讨抑郁症患者认知功能障碍的特征及其与血清脑源性神经营养因子(BDNF)水平的关系。方法采用北京版蒙特利尔认知评估量表(MoCA-BJ)分别对73例抑郁症患者和71例正常人进行认知功能评定, 根据MoCA-BJ得分, 将抑郁症患者划分为伴认知功能障碍组, 共36例;不伴认知功能障碍组, 共37例。采用酶联免疫吸附法(ELISA)测定所有受试者血清BDNF水平。结果抑郁症患者MoCA总分、视空间功能、执行功能、注意力、延迟记忆功能、时间定向力、地点定向力功能均低于正常对照组(P<0.05);抑郁症患者认知功能障碍发生率为49.3%;伴认知障碍组[(12.08±7.08)ng/ml]与不伴认知障碍组[(12.22±7.93)ng/ml]的血清BDNF水平差异无统计学意义(P>0.05), 但两组BDNF水平均低于对照组[(16.55±7.47)ng/ml, P<0.01], 血清BDNF水平与抑郁症患者各认知域功能无显著相关(P>0.05)。结论抑郁症患者认知损害累及视空间、执行功能、延迟记忆、注意力、定向力等多个认知领域。血清BDNF水平与抑郁症关系密切, 但与抑郁症认知功能无明显关系。

引用

页码：710 / 712

页数：3

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