基因多态性与氯吡格雷抵抗的研究进展

被引:2
作者
何咏聪
区文超
机构
[1] 广州医科大学附属第二医院心内科、广州心血管研究所
关键词
氯吡格雷抵抗; 定义; 受体; 位点; 基因多态性; 遗传多态性; 血小板聚集;
D O I
10.13820/j.cnki.gdyx.2014.21.051
中图分类号
R54 [心脏、血管(循环系)疾病];
学科分类号
1002 ; 100201 ;
摘要
<正>氯吡格雷是一种噻吩吡啶类衍生物,经过肠道吸收后,约85%被酯酶水解成非活性物质,剩下的15%在肝脏经过一系列的CYP450酶转化有活性的代谢产物后[1],与血小板表面二磷酸腺苷(ADP)受体P2Y12不可逆结合,阻断ADP对腺苷环化酶的抑制作用,最终抑制纤维蛋白原受体(GPⅡb/Ⅲa)活化,从而抑制血小板的聚集。目前,氯吡格雷已经是广泛应用于临床的抗血小板药物。然而,在服用氯吡格雷
引用
收藏
页码:3418 / 3420
页数:3
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