心力衰竭的能量代谢重构及其治疗

被引：31

作者：

苏冠华 ^{[1
]}

孙雨霏 ^{[2
]}

卢永昕 ^{[1
]}

机构：

[1] 华中科技大学同济医学院附属协和医院心内科

[2] 武汉市普爱医院心内科

来源：

国际心血管病杂志 | 2012年 / 39卷 / 02期

关键词：

心力衰竭; 能量代谢; 肉碱脂酰转移酶; 曲美他嗪; 左卡尼汀;

D O I：

暂无

中图分类号：

R541.6 [血液循环衰竭];

学科分类号：

1002 ; 100201 ;

摘要：

在心力衰竭发生发展的过程中,肥厚和衰竭的心肌往往发生了能量和底物代谢的改变,并直接或间接地促进了心肌重构的发展,即心肌的能量"代谢重构"。针对这一靶点,通过哌克昔林、曲美他嗪、左卡尼汀等药物抑制游离脂肪酸的摄取、β-氧化或直接促进葡萄糖代谢,均可能进一步优化心肌的能量底物代谢,更好地保存或改善心肌功能,延缓心力衰竭的进展。

引用

页码：65 / 67

页数：3

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