脑梗死超急性期血清泛素C末端水解酶-1的变化及意义

被引：7

作者：

张炜 ^{[1
]}

苏萍 ^{[1
]}

邝兆威 ^{[2
]}

机构：

[1] 广东省东莞市塘厦医院神经内科

[2] 广东省东莞市塘厦医院检验科

来源：

实用医学杂志 | 2013年 / 29卷 / 11期

关键词：

脑梗死; 泛素C末端水解酶-1; 生物标志物; 预后;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

目的:探讨脑梗死超急性期血清泛素C末端水解酶-1(ubiquitin C-terminal hydrolase-L1,UCH-L1)水平的变化及意义。方法:连续观察发病6 h内表现为急性局灶性神经功能缺损的患者,分为超急性期脑梗死(hyperacute cerebral infarct,HCI)组(46例)和短暂性脑缺血发作(transient ischemic attack,TIA)组(30例)。用夹心ELISA测定两组患者血清(发病6 h内)UCH-L1并进行比较。分析脑梗死超急性期血清UCH-L1水平与NIHSS评分、脑梗死体积、mRS评分的相关性。结果:HCI组、TIA组血清UCH-L1水平分别为0.21(0.20)μg/L、0.13(0.07)μg/L,HCI组血清UCH-L1水平显著高于TIA组(Z=-4.047,P<0.001)。HCI组血清UCH-L1水平与脑梗死体积[6.70(10.50)mL]呈正相关(r=0.751,P<0.001);与入院时NIHSS评分[9(8)分](r=0.589,P<0.001)、入院7 d NIHSS评分[7(8.25)分](r=0.563,P<0.001)正相关;与3个月后mRS评分[2(3)分]正相关(r=0.554,P<0.001)。Logistic回归分析显示,UCH-L1增高与高mRS评分(发病3个月后)独立相关(OR=3.275;95%CI:1.642～13.726;P:0.029)。结论:脑梗死超急性期血清UCH-L1水平可能预示了病情严重程度和预后。

引用

页码：1797 / 1799

页数：3

共 6 条

[1] 各类脑血管疾病诊断要点 [J].

中华神经科杂志, 1996, (06) :60-61

[2] Clinical Utility of Serum Levels of Ubiquitin C-Terminal Hydrolase as a Biomarker for Severe Traumatic Brain Injury [J].

Mondello, Stefania ;

Linnet, Akinyi ;

Buki, Andras ;

Robicsek, Steven ;

Gabrielli, Andrea ;

Tepas, Joseph ;

Papa, Linda ;

Brophy, Gretchen M. ;

Tortella, Frank ;

Hayes, Ronald L. ;

Wang, Kevin K. .

NEUROSURGERY, 2012, 70 (03) :666-675

[3] Identification and Preliminary Characterization of Ubiquitin C Terminal Hydrolase 1 (UCHL1) as a Biomarker of Neuronal Loss in Aneurysmal Subarachnoid Hemorrhage [J].

Lewis, Stephen B. ;

Wolper, Regina ;

Chi, Yueh-Yun ;

Miralia, Lynn ;

Wang, Yong ;

Yang, Cui ;

Shaw, Gerry .

JOURNAL OF NEUROSCIENCE RESEARCH, 2010, 88 (07) :1475-1484

[4] Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats [J].

Liu, Ming C. ;

Akinyi, Linnet ;

Scharf, Dancia ;

Mo, Jixiang ;

Larner, Stephen F. ;

Muller, Uwe ;

Oli, Monika W. ;

Zheng, Wenrong ;

Kobeissy, Firas ;

Papa, Linda ;

Lu, Xi-Chun ;

Dave, Jitendra R. ;

Tortella, Frank C. ;

Hayes, Ronald L. ;

Wang, Kevin K. W. .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2010, 31 (04) :722-732

[5] Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury [J].

Papa, Linda ;

Akinyi, Linnet ;

Liu, Ming Cheng ;

Pineda, Jose A. ;

Tepas, Joseph J., III ;

Oli, Monika W. ;

Zheng, Wenrong ;

Robinson, Gillian ;

Robicsek, Steven A. ;

Gabrielli, Andrea ;

Heaton, Shelley C. ;

Hannay, H. Julia ;

Demery, Jason A. ;

Brophy, Gretchen M. ;

Layon, Joe ;

Robertson, Claudia S. ;

Hayes, Ronald L. ;

Wang, Kevin K. W. .

CRITICAL CARE MEDICINE, 2010, 38 (01) :138-144

[6]

PGP9.5, a ubiquitin C-terminal hydrolase;pattern of mRNA and protein expression during neural development in the mouse[J] . Julian N. Schofield,Ian N.M. Day,Rod J. Thompson,Yvonne H. Edwards. Developmental Brain Research . 1995 (2)

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