急性缺血性脑卒中患者的阿司匹林抵抗与预后的相关性

被引：10

作者：

龚雪琴 ^{[1
]}

杨超 ^{[1
]}

胡继川 ^{[1
]}

王云甫 ^{[2
]}

机构：

[1] 武汉市东西湖区人民医院神经内科

[2] 十堰市太和医院神经内科

来源：

神经损伤与功能重建 | 2013年 / 06期

关键词：

急性脑卒中; 阿司匹林抵抗; 缺血性卒中; 死亡率; 卒中复发;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

目的:探讨急性缺血性脑卒中患者中阿司匹林抵抗(AR)的发生率及其与预后的关系。方法:连续入选212例急性缺血性脑卒中患者,入院当天开始服用阿司匹林,7～10 d后检测血小板聚集率,筛选出AR患者(AR组)及阿司匹林敏感AS患者(AS组),并进行3～24个月随访,观察随访期间缺血性卒中的再发以及死亡情况,采用Logistic回归分析AR发生的危险因素及其与死亡率的关系。结果:AR 68例(32.1%),AS144例(67.9%);2组一般资料差异无统计学意义;AR组发生缺血性卒中14例(20.6%),全因死亡22例(32.4%);AS组缺血性卒中19例(13.2%),全因死亡24例(16.7%);AR组死亡率高于AS组,差异有统计学意义(P=0.010),缺血性卒中复发率差异无统计学意义。AR(P=0.027)、NIHSS得分(P=0.003)及年龄(P=0.029)是急性缺血性卒中患者2年死亡率的独立危险因素。结论:急性缺血性卒中患者中AR发生率高,AR与急性缺血性卒中患者2年死亡率密切相关。

引用

页码：435 / 439

页数：5

共 11 条

[1] Biochemical Aspirin Resistance and Recurrent Lesions in Patients with Acute Ischemic Stroke [J].

Jeon, Sang-Beom ;

Song, Ha-Sup ;

Kim, Bum Joon ;

Kim, Hye-Jin ;

Kang, Dong-Wha ;

Kim, Jong S. ;

Kwon, Sun U. .

EUROPEAN NEUROLOGY, 2010, 64 (01) :51-57

[2] A pilot study of resistance to aspirin in stroke patients [J].

Bennett, Daniel ;

Yan, Bernard ;

MacGregor, Lachlan ;

Eccleston, David ;

Davis, Stephen M. .

JOURNAL OF CLINICAL NEUROSCIENCE, 2008, 15 (11) :1204-1209

[3]

Aspirin resistance determined with PFA-100 does not predict new thrombotic events in patients with stable ischemic cerebrovascular disease[J] . Giorgio B. Boncoraglio,Antonella Bodini,Carla Brambilla,Elena Corsini,Maria R. Carriero,Eugenio A. Parati.Clinical Neurology and Neurosurgery . 2008 (3)

[4] Update to the AHA/ASA recommendations for the prevention of stroke in patients with stroke and transient ischemic attack [J].

Adams, Robert J. ;

Albers, Greg ;

Alberts, Mark J. ;

Benavente, Oscar ;

Furie, Karen ;

Goldstein, Larry B. ;

Gorelick, Philip ;

Halperin, Jonathan ;

Harbaugh, Robert ;

Johnston, S. Claiborne ;

Katzan, Irene ;

Kelly-Hayes, Margaret ;

Kenton, Edgar J. ;

Marks, Michael ;

Sacco, Ralph L. ;

Schwamm, Lee H. .

STROKE, 2008, 39 (05) :1647-1652

[5]

Aspirin "Resistance" and Risk of Cardiovascular Morbidity: Systematic Review and Meta-Analysis[J] . BMJ: British Medical Journal . 2008 (7637)

[6]

Aspirin resistance in secondary stroke prevention[J] . J.Berrouschot,B.Schwetlick,G.Twickel,C.Fischer,H.Uhlemann,T.Siegemund,A.Siegemund,A.Roessler.Acta Neurologica Scandinavica . 2005 (1)

[7]

Screening for Aspirin Responsiveness After Transient Ischemic Attack and Stroke: Comparison of 2 Point-of-Care Platelet Function Tests With Optical Aggregometry[J] . Paul Harrison,Helen Segal,Kevin Blasbery,Charlene Furtado,Louise Silver,Peter M. Rothwell.Stroke . 2005 (5)

[8]

Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial[J] . Hans-Christoph Diener,Julien Bogousslavsky,Lawrence M Brass,Claudio Cimminiello,Laszlo Csiba,Markku Kaste,Didier Leys,Jordi Matias-Guiu,Hans-Jürgen Rupprecht.The Lancet . 2004 (9431)

[9]

Effects of Aspirin Dose When Used Alone or in Combination With Clopidogrel in Patients With Acute Coronary Syndromes: Observations From the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) Study[J] . Ron J.G. Peters,Shamir R. Mehta,Keith A.A. Fox,Feng Zhao,Basil S. Lewis,Steven L. Kopecky,Rafael Diaz,Patrick J. Commerford,Vicent Valentin,Salim Yusuf.Circulation: Journal of the American Heart Association . 2003 (14)

[10]

A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease[J] . Patricia A Gum,Kandice Kottke-Marchant,Patricia A Welsh,Jennifer White,Eric J Topol.Journal of the American College of Cardiology . 2003 (6)

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