小胶质细胞与脑缺血

被引：6

作者：

宋玉成

刘永海

机构：

[1] 徐州医学院附属医院神经内科

来源：

国际脑血管病杂志 | 2006年 / 06期

关键词：

小胶质细胞; 脑缺血;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

小胶质细胞是脑内的主要免疫效应细胞,在神经元的生理活动中起支持、营养、保护和修复等重要功能。脑缺血后,小胶质细胞迅速活化和增殖,发挥巨噬细胞的吞噬效应,并通过产生神经毒性分子和神经营养因子发挥双重作用。因此,研究小胶质细胞与脑缺血的关系,充分发挥其保护功能,降低其损害作用,将有助于提高缺血性脑损伤的救治效果。

引用

页码：456 / 458

页数：3

共 10 条

[1] Quantitative morphological study of microglial cells in the ischemic rat brain using principal component analysis [J].

Soltys, Z ;

Orlowski, D ;

Zaremba, M ;

Orlowski, D ;

Piechota, M ;

Fiedorowicz, A ;

Janeczko, K ;

Oderfeld-Nowak, B .

JOURNAL OF NEUROSCIENCE METHODS, 2005, 146 (01) :50-60

[2]

Neuropeptide PACAP inhibits hypoxic activation of brain microglia: a protective mechanism against microglial neurotoxicity in ischemia[J] . Kyoungho Suk,Jae-Hoon Park,Won-Ha Lee.Brain Research . 2004 (1)

[3] Delayed expressed TNFR1 co-localize with ICAM-1 in astrocyte in mice brain after transient focal ischemia [J].

Yin, L ;

Ohtaki, H ;

Nakamachi, T ;

Kudo, Y ;

Makino, R ;

Shioda, S .

NEUROSCIENCE LETTERS, 2004, 370 (01) :30-35

[4]

Microglia:Neuroprotective and Neurotrophic Cells in the Central Nervous System[J] . Kazuyuki Nakajima,Shinichi Kohsaka.Current Drug Target -Cardiovascular & Hematologic . 2004 (1)

[5]

Accelerated Glial Reactivity to Stroke in Aged Rats Correlates with Reduced Functional Recovery[J] . I. Badan,B. Buchhold,A. Hamm,M. Gratz,L. C. Walker,D. Platt,Ch. Kessler,A. Popa-Wagner.Journal of Cerebral Blood Flow & Metabolism . 2003 (7)

[6]

Ibudilast, a phosphodiesterase inhibitor, protects against white matter damage under chronic cerebral hypoperfusion in the rat[J] . Hideaki Wakita,Hidekazu Tomimoto,Ichiro Akiguchi,Jin-Xi Lin,Masafumi Ihara,Ryo Ohtani,Masunari Shibata.Brain Research . 2003 (1)

[7] Cell cycle protein expression in proliferating microglia and astrocytes following transient global cerebral ischemia in the rat [J].

Kato, H ;

Takahashi, A ;

Itoyama, Y .

BRAIN RESEARCH BULLETIN, 2003, 60 (03) :215-221

[8] Stromelysin-1 and gelatinase A are upregulated before TNF-α in LPS-stimulated neuroinflammation [J].

Mun-Bryce, S ;

Lukes, A ;

Wallace, J ;

Lukes-Marx, M ;

Rosenberg, GA .

BRAIN RESEARCH, 2002, 933 (01) :42-49

[9] Nonactivated microglia promote oligodendrocyte precursor survival and maturation through the transcription factor NF-κB [J].

Nicholas, RS ;

Wing, MG ;

Compston, A .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2001, 13 (05) :959-967

[10]

Up regulation of Kvl.3 K+ channels in microglia deactivated by TGF-β .2 Schilling T,Quandt FN,Cherny VV,Zhou W,Heinemann U,Decoursey TE,Eder C. Am J Physiol Cell Physiol . 2000

← 1 →