不稳定型心绞痛患者血浆纤维蛋白原和C-反应蛋白含量的变化

被引:5
作者
彭雯
张湖萍
文晖
成蓓
机构
[1] 华中科技大学同济医学院协和医院综合科
关键词
心绞痛; 纤维蛋白原; C反应蛋白;
D O I
暂无
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)];
学科分类号
1002 ; 100201 ;
摘要
目的:探讨血浆纤维蛋白原含量(Fib)在不稳定型心绞痛(UAP)发展过程中的变化。方法:65例患者分为3组:UAP组(n=23)、稳定型心绞痛(SAP)组(n=22)和对照组(n=20)。UAP组又分为有并发症组(n=17)和无并发症组(n=6)两个亚组。入院时取静脉血检查血糖、血脂、血浆Fib水平和肝、肾功能、C反应蛋白(CRP)等。UAP组48h后重复检测Fib和CRP。结果:UAP组CRP、Fib血浆水平明显高于对照组(P<0.01);SAP组CRP、Fib血浆水平与对照组相比差异有显著性(P<0.05);入院时,有并发症组血浆Fib和CRP水平高于无并发症组(P<0.01);48h后,有并发症组的Fib、CRP血浆水平较入院时高(P<0.05),而无并发症组较入院时差异无显著性(P>0.05)。结论:48h前后血浆Fib和CRP水平的变化,可能反映了疾病的活动程度和预后。
引用
收藏
页码:55 / 56+85+88 +85
页数:4
相关论文
共 8 条
[1]  
Fibrinogen, viscosity, and white blood cell count are major risk factors for ischem ic heart disease,Tcaerphilly and speed well collaborative heart daiseases studies. Yarnell JWG,Baker IA,Sweetnam PM,et al. Circulation . 1991
[2]  
Recent progress in the clinical agents of fibrinogen. Keenig W. European Heart Journal . 1995
[3]  
The genetic contribution to the risk of thrombosis and cardiovas2 cular disease. Humphries SE. Trends in Cardiovascular Medicine . 1994
[4]  
Fibrinogen as cardiovascular risk factor : A meta2 analysis and review of the literature. Ernst E,Resch KL. Annals of Internal Medicine . 1993
[5]  
Elevated level of plasma C-reactive protein in patients with unstable angina: its relations with coronary stenosis and lipid profile.. Li JJ,Jiang H,Huang CX,Fang CH,Tang QZ,Xia H,Liu J,Li GS. Angiology . 2002
[6]  
Plasma fibrinogen and fibrinogen geno2 types in 4 6 8 5 cases of myocardial infarction and in 6 0 0 2 controls: test of cansalityby endelian randomization. Youngman LD,Keavney BD,Palmer A. Circulation . 2000
[7]  
Mendelian randomization:can genetic epidemiology contribute to understanding environmental determinants of disease. George Davey Smith,Shah Ebrahim. International Journal of Epidemiology . 2003
[8]  
Analysis of gene environment interaction in coronary heart disease : Fibrinogen polymorphisms as an example. Michela Vischetti,Francesco Zito,Maria Benedetta Donati, et al. Italian Heart Journal . 2002