游离脂肪酸对血管内皮细胞影响的研究进展

被引：2

作者：

詹晓蓉

机构：

[1] 解放军总医院内分泌科北京

来源：

国外医学(内分泌学分册) | 2003年 / 04期

关键词：

游离脂肪酸; 血管内皮细胞; 损伤;

D O I：

暂无

中图分类号：

R587.2 [糖尿病性昏迷及其他并发症];

学科分类号：

1002 ; 100201 ;

摘要：

游离脂肪酸(FFAs)升高是胰岛素抵抗的突出特点,血中明显升高的FFAs可导致血管内皮细胞功能损伤。其发生的机制可能与肿瘤坏死因子-α(TNF-α)诱导的致细胞凋亡的蛋白过度表达、内皮细胞一氧化氮合酶(NOS)活性改变和细胞因子刺激内皮细胞神经酰胺的产生有关。花生四烯酸作为多不饱和脂肪酸成分之一,其代谢产物对细胞有保护作用。

引用

页码：266 / 268

页数：3

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