神经生长因子对大鼠局灶性脑缺血再灌注后细胞凋亡的影响

被引：35

作者：

刁士元

机构：

[1] 中国人民解放军第四六三医院沈阳

来源：

临床神经病学杂志 | 2004年 / 06期

关键词：

神经生长因子; 缺血再灌注; 细胞凋亡;

D O I：

暂无

中图分类号：

R743 [脑血管疾病];

学科分类号：

1002 ;

摘要：

目的　探讨大鼠局灶性脑缺血再灌注后神经生长因子 (NGF)对细胞凋亡的影响。方法　应用原位缺口末端标记 (TUNEL)法检测大鼠大脑中动脉线栓法阻断 2h ,再灌注 2 2h ,细胞凋亡情况及静脉注射NGF对细胞凋亡的影响。结果　缺血 2h ,再灌注 2 2h ,梗死区可见大量凋亡细胞 (2 4 8.4 2± 2 4 .37) ,静脉注射NGF后梗死区凋亡细胞明显减少 (190 .2 5± 2 5 .4 7) (P <0 0 1)。结论　局灶性脑缺血再灌注后细胞凋亡增加 ,静脉给予NGF可减少脑细胞凋亡

引用

页码：450 / 451

页数：2

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