普罗布考抗动脉粥样硬化发生机制的研究

被引：6

作者：

张梦云

严光

机构：

[1] 安徽医科大学附属省立医院安徽省立医院老年医学科

来源：

中国临床保健杂志 | 2015年 / 18卷 / 06期

关键词：

普罗布考; 型糖尿病; BI; 抗氧化作用; 屏氧酶; 动脉粥样硬化; 动脉硬化; HDL; 胆固醇流出;

D O I：

暂无

中图分类号：

R543.5 [动脉疾病];

学科分类号：

1002 ; 100201 ;

摘要：

<正>动脉粥样硬化(AS)是由多种遗传及环境因素参与的慢性炎症免疫反应性疾病[1-4],是心脑血管事件发生的病理学基础,目前动脉粥样硬化的发病机制尚未阐明。普罗布考对非家族性高胆固醇血症和家族性纯合子及杂合子型高胆固醇血症均有明显的降低作用,后因其可降低高密度脂蛋白胆固醇(HDL-C)水平及延长QT间期使其临床应用受到限制,以往观点认为HDL-C水平与冠心病风险呈负相

引用

页码：669 / 672

页数：4

共 25 条

[1]

炎症与氧化应激在大鼠动脉粥样硬化中的作用及药物干预研究.[D].李云攀.青岛大学.2014, 01

[2]

普罗布考治疗颈动脉易损斑块的临床研究.[D].李志军.天津医科大学.2014, 01

[3]

普罗布考在动脉粥样硬化模型中改善高密度脂蛋白功能的研究.[D].钟建开.南方医科大学.2011, 05

[4] Probucol Protects Against Atherosclerosis Through Lipid-lowering and Suppressing Immune Maturation of CD11c+ Dendritic Cells in STZ-induced Diabetic LDLR-/- Mice [J].

Zhu, Hong ;

Jin, Xueting ;

Zhao, Jingjing ;

Dong, Zhen ;

Ma, Xin ;

Xu, Fang ;

Huang, Wei ;

Liu, George ;

Zou, Yunzeng ;

Wang, Keqiang ;

Hu, Kai ;

Sun, Aijun ;

Ge, Junbo .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2015, 65 (06) :620-627

[5] Probucol plus cilostazol attenuate hypercholesterolemia-induced exacerbation in ischemic brain injury via anti-inflammatory effects [J].

Kim, Ji Hyun ;

Hong, Ki Whan ;

Bae, Sun Sik ;

Shin, Yong-Il ;

Choi, Byung Tae ;

Shin, Hwa Kyoung .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2014, 34 (03) :687-694

[6] Probucol and cilostazol exert a combinatorial anti-atherogenic effect in cholesterol-fed rabbits [J].

Chen, Yulong ;

Zhao, Sihai ;

Huang, Bingqiao ;

Wang, Yanli ;

Li, Yafeng ;

Waqar, Ahmed Bilal ;

Liu, Ruihan ;

Bai, Liang ;

Fan, Jianglin ;

Liu, Enqi .

THROMBOSIS RESEARCH, 2013, 132 (05) :565-571

[7] Effects of probucol on angiotensin II-induced BMP-2 expression in human umbilical vein endothelial cells [J].

Zhang, Ming ;

Wang, Jian ;

Liu, Jing-Hua ;

Chen, Shu-Juan ;

Zhen, Bin ;

Wang, Chang-Hua ;

He, Hua ;

Jiang, Chen-Xi .

MOLECULAR MEDICINE REPORTS, 2013, 7 (01) :177-182

[8] Inhibition of Suicidal Erythrocyte Death by Probucol [J].

Shaik, Nazneen ;

Lupescu, Adrian ;

Lang, Florian .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2013, 61 (02) :120-126

[9]

Probucol; a lipid-lowering drug; prevents cognitive and hippocampal synaptic impairments induced by amyloid β peptide in mice.[J].Danúbia B. Santos;Kaite C. Peres;Renata P. Ribeiro;Dirleise Colle;Alessandra A. dos Santos;Eduardo L.G. Moreira;Diogo O.G. Souza;Cláudia P. Figueiredo;Marcelo Farina.Experimental Neurology.2011, 2

[10]

Probucol therapy improves long-term (>10-year) survival after complete revascularization: A propensity analysis.[J].Takatoshi Kasai;Katsumi Miyauchi;Naozumi Kubota;Kan Kajimoto;Atsushi Amano;Hiroyuki Daida.Atherosclerosis.2011, 2

← 1 2 3 →