基质金属蛋白酶-9与神经系统疾病

被引：3

作者：

张晓蕴

李小刚

机构：

[1] 泸州医学院神经内科

来源：

中国临床神经科学 | 2008年 / 03期

关键词：

基质金属蛋白酶; 脑缺血; 肌萎缩性侧索硬化; 多发性硬化; 脊髓病; 脑炎; 帕金森病; 阿尔茨海默病;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

1002 ;

摘要：

基质金属蛋白酶-9（MMP-9）是一种Zn2+依赖性蛋白水解酶,能降解和重塑细胞外基质,破坏血脑屏障,介导炎症反应,促进神经细胞死亡,同时也有利于运动功能的恢复。MMP-9激活和调控与神经系统疾病的发病机制有密切的关系。MMP-9是研究过程中发现的新靶点,为神经系统疾病的早期诊断、并发症的预防和治疗开辟了新的途径,为神经系统疾病患者的治疗带来曙光。

引用

页码：312 / 317

页数：6

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