超敏C-反应蛋白结合同型半胱氨酸预测急性缺血性脑卒中短期预后

被引：15

作者：

刘小野 ^{[1
]}

董浩 ^{[2
,3
]}

涂文军 ^{[2
,1
]}

王屹 ^{[2
,1
]}

陈惠 ^{[2
,3
]}

机构：

[1] 首都医科大学附属北京友谊医院

[2] 首都医科大学康复医学院

[3] 中国康复研究中心

来源：

中国康复理论与实践 | 2014年 / 04期

关键词：

急性缺血性脑卒中; 超敏C-反应蛋白; 同型半胱氨酸; 预后; 短期;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

目的研究超敏C-反应蛋白(Hs-CRP)和同型半胱氨酸(HCY)水平与急性缺血性脑卒中短期预后的关联性。方法前瞻性研究189例首次发病的急性缺血性脑卒中患者。入院后进行血清Hs-CRP、HCY水平检测与美国国立卫生研究院卒中量表(NIHSS)评分。入院90 d后通过改良Rankin量表(mRS)测定短期功能结果。结果脑卒中组血清Hs-CRP和HCY水平显著高于健康对照组(P<0.001)。调整NIHSS和年龄等其他危险因素后,Hs-CRP和HCY是功能结果和死亡的独立的预测因素。通过受试者操作特征曲线(ROC)曲线下面积分析,HCY和HS-CRP结合模型的预测准确度明显高于各生物标志物单独测量和NIHSS评分。结论 HsCRP和HCY是脑卒中短期预后的独立预测因素。组合模型可以提供额外的预后信息。

引用

页码：347 / 350

页数：4

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