糖原合成激酶3β抑制剂增强异氟醚后处理对心肌缺血-再灌注损伤的保护作用

被引：6

作者：

白延丽

沈途

刘国利

张锦英

机构：

[1] 辽宁医学院附属第一医院麻醉科

来源：

临床麻醉学杂志 | 2012年 / 28卷 / 10期

关键词：

SB216763; 异氟醚; 后处理; 心肌缺血-再灌注; 线粒体通透性转化孔;

D O I：

暂无

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

目的探讨糖原合成激酶(GSK)3β抑制剂SB216763是否增强异氟醚(ISO)后处理对心肌缺血-再灌注损伤的保护作用。方法雄性新西兰白兔,体重2.5～3.0kg,将模型制备成功的48只白兔随机分为八组(n=6),缺血-再灌注组(A组);ISO0.5MAC组(B组)或1.0MAC组(C组);GSK3β抑制剂SB216763(SB)0.2mg/kg组(D组)或0.6mg/kg(E组);ISO+SB组(F组);SB+苍术苷(Atr)组(G组);ISO+SB+Atr组(H组)。于缺血前(基础值,T0)、缺血30min(T1)、再灌注30min(T2)、60min(T3)和120min(T4)时分别记录HR和MAP;再灌注结束时,TTC法染色心肌切片并计算心肌梗死面积的百分比。结果 T0时各组血液动力学指标差异无统计学意义。与T0时比较,各组T3、T4时HR明显减慢、T2～T4时MAP明显降低(P<0.05)。与A组比较,C组、E组和F组心肌梗死面积明显缩小(P<0.05)。苍术苷废除了E组和F组的保护作用。结论 GSK3β抑制剂能够增强异氟醚后处理对心肌缺血-再灌注损伤的保护作用,并且该过程经由线粒体通透性转化孔调控。

引用

页码：1010 / 1012

页数：3

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