基质金属蛋白酶-9基因多态性与颈动脉粥样硬化微栓子形成的相关性研究

被引：4

作者：

沈焱 ^{[1
]}

白向东 ^{[2
]}

马瑞莲 ^{[2
]}

杜秦川 ^{[2
]}

张淑敏 ^{[2
]}

魏欣 ^{[2
]}

李玲 ^{[2
]}

高志嵩 ^{[2
]}

程继明 ^{[2
]}

邓长林 ^{[2
]}

王静 ^{[2
]}

机构：

[1] 宁夏医科大学

[2] 宁夏银川市第一人民医院神经内科

来源：

宁夏医学杂志 | 2013年 / 35卷 / 03期

关键词：

基质金属蛋白酶-9(MMP-9); 缺血性脑血管病; 颈动脉粥样硬化不稳定斑块; 微栓子;

D O I：

10.13621/j.1001-5949.2013.03.025

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

目的研究颈动脉粥样硬化微栓子阳性是否与基质金属蛋白酶-9(MMP-9)基因启动子C-1562T的多态性有相关性,为脑血管疾病的早期预防、诊断及治疗提供帮助。方法对被确诊为缺血性脑血管病的患者行颈动脉超声检查,筛选出患颈动脉粥样硬化不稳定斑块的患者120例,再行彩色经颅多普勒超声(TCD)监测微栓子,将其划分为微栓子阳性组63例与微栓子阴性组57例,用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术对MMP-9基因启动子C-1562T位点进行基因分型,并随机抽取10%的样本对MMP-9基因启动子C-1562T的基因型进行直接测序证实。统计2组患者中C-1562T的基因型、等位基因频率,并分析MMP-9基因启动子C-1562T的多态性是否与微栓子阳性有相关性。结果微栓子阳性组CT型和TT型明显高于微栓子阴性组,2组比较差异有统计学意义(χ2=32.568,P<0.05);MMP-9的T等位基因是微栓子形成的危险因素(OR=10.000,P<0.05)。结论 MMP-9基因启动子C-1562T基因多态性与微栓子形成密切相关。

引用

页码：207 / 210+192 +192

页数：5

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