蚯蚓提取物治疗原发性肾小球疾病高凝状态

被引：1

作者：

邵凤民

张小玲

程银桢

王小阳

朱长连

邢清和

张明轩

机构：

[1] 河南省人民医院肾内科!郑州

[2] 河南医科大学三附院儿科!郑州

[3] 河南医科大学三附院药剂科!郑州

[4] 河南医科大学一附院肾内科!郑州

来源：

中国临床药学杂志 | 1999年 / 06期

关键词：

蚯蚓提取物; 原发性肾病综合征; 慢性肾小球肾炎; 高凝状态;

D O I：

10.19577/j.cnki.issn10074406.1999.06.011

中图分类号：

R277.5 [中医泌尿学];

学科分类号：

1005 ;

摘要：

目的:探讨蚯蚓提取物对原发性肾小球疾病中凝血、抗凝、纤溶功能及血液流变学的影响.方法:对36例原发性肾病综合征和30例慢性肾小球肾炎给予po蚯蚓提取物150mg/次,tid,连用14d,在用药前后采血测定凝血、抗凝、纤溶及血液流变学指标.结果:治疗后血KPTT、PT、TT较治疗前明显延长(P<0.01、P<0.05),AT-Ⅲ及t-PA活性在治疗后较治疗前明显升高(P<0.001,P<0.01),FDP含量较治疗前也明显上升(P<0.01),血液流变学指标较治疗前均有显著改善(P<0.05、P<0.01).结论:蚯蚓提取物具有抗凝、纤溶的功能,po蚯蚓提取物能改善肾小球疾病的高凝状态.

引用

页码：363 / 365

页数：3

共 6 条

[1]

Latent tissue plasminogen activator produced by human endothelial cells in culture:Evidence for an enzymeinhibitor complex. Levin EG,Naragaj GR,Takiee T,et al. Proceedings of the National Academy of Sciences of the United States of America . 1996

[2]

Clinical correlation betwen hypercoagulability and thromboetic phenomenon. Rober A,Kitera J,Broteory EG,et al. Thrombosis Research . 1994

[3]

A possibility of earthworm powder as therapeutic agent for thrombosis. Mihara H,Fine LJ,Okuda S,et al. Thrombosis and Haemostasis . 1989

[4]

Fibrinolytic activity of the earthworm extract. Park K,Kye C,Lee M,et al. Thrombosis and Haemostasis . 1989

[5]

Coagulation and fibrinolysis in patients with chronic renal failure and undergoing conservative trcatment. Tomura S,Nakamura Y,Deguchi F,et al. Thrombosis Research . 1991

[6]

Two different macha-nisms in patients with venous thrombosis and defective fibrinolysis:Low concentration of plasminogen activator or increased concentration of plasminogen activator inhibitor. Nilsson IM,Nisch R,Fox JW f,et al. British Medical Journal . 1995

← 1 →