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Hyperhomocysteinemia is associated with in inpaired endothelium dependent vasodilation in humens. Tawakol A, Omland J, Gerhard M, et al. Circulation . 1997
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An atherogenic stimulus homcysteine inhibits cofactor activity of thrombomdulin and enhances thrombodulin expression in human umbilical vein endothelial cells. Hayashi T, Honda G, Sunznki K. Blood . 1992