The effects of D-glucosamine schiff base and its metal complexes on the growth of Aerobacter aerogenes were investigated by the microcalorimetry. Among the substances tested. Zn-SG was shown to be the most bacteriostasic, followed by Zn-o-VGand SG (with the Ic50 of 242, 287 and 320 μg.mL-1, respectively). Cu(Ⅱ)-SG showedless inhibitory effect on Aerobacter aerogenes over the concentration rang of 50 ~ 300μg. mL-1.