谷氨酸与缺血性卒中早期神经功能恶化

被引：6

作者：

王阳 ^{[1
,2
]}

姜建东 ^{[1
,2
]}

机构：

[1] 蚌埠医学院附属连云港医院

[2] 连云港市第二人民医院神经内科

来源：

国际脑血管病杂志 | 2013年 / 02期

关键词：

卒中; 脑缺血; 谷氨酸; 生物学标记; 疾病恶化;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

缺血性卒中早期神经功能恶化(early neurological deterioration,END)的机制尚不明确,也缺乏可靠的预测因素和有效的防治措施。谷氨酸介导的兴奋性毒性机制在缺血事件级联反应中发挥着很重要的作用。血浆谷氨酸水平增高是END的重要预测因素之一。研究表明,兴奋性氨基酸转运体-2基因启动子区多态性是个体对END易感性的潜在原因。一些拮抗谷氨酸能通路的治疗策略可作为干预END的策略。

引用

页码：132 / 137

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