老年脑梗死病人血清细胞因子含量及其动态变化

被引：40

作者：

张清华 ^{[1
]}

崔元孝 ^{[1
]}

刘敬花 ^{[2
]}

郑茂永 ^{[1
]}

冯建利 ^{[1
]}

潘宁 ^{[1
]}

王晓红 ^{[1
]}

张桂茹 ^{[1
]}

机构：

[1] 山东大学附属山东省立医院神经内科

[2] 山东省交通医院神经内科

来源：

中国老年学杂志 | 2009年 / 29卷 / 18期

关键词：

脑梗死; 白介素-6; 肿瘤坏死因子-α; 预后; 脑梗死体积;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

目的研究老年脑梗死病人血清中IL-6、TNF-α含量的动态变化及其与脑梗死体积及预后的关系。方法72例病人及70例健康对照者来自山东大学附属省立医院,均于出现症状24h内入组。在确诊当时及第1、2、3、4、6、10天各留取血液标本,测定血清IL-6、TNF-α水平。梗死体积为发病第7天CT测得。神经功能恢复评定标准为修正的Rankin等级评分。结果病例组入院时IL-6水平达到高峰(0.95±0.18)ng/L,至第3天又出现高峰(0.90±0.21)ng/L,各时点IL-6水平高于对照组(P<0.01),其含量与脑梗死体积及Rankin等级评分有相关性。各观察时点TNF-α与对照组无显著差别。结论IL-6能反映脑卒中时脑组织的损害程度,并且与病人预后密切相关,血清IL-6含量在发病早期升高,可以作为老年脑梗死早期敏感的诊断指标。

引用

页码：2310 / 2312

页数：3

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