载脂蛋白E基因多态性与缺血性脑血管病的关系

被引：3

作者：

邓芝蕙

叶文翔

姜昭

刘明洲

穆红

机构：

[1] 天津第一中心医院脑内科

[2] 天津第一中心医院脑内科 ()

[3] ()

来源：

中国临床神经科学 | 2000年 / 01期

关键词：

载脂蛋白E; 基因多态性; 动脉粥样硬化; 缺血性脑血管病;

D O I：

暂无

中图分类号：

R743 [脑血管疾病];

学科分类号：

1002 ;

摘要：

目的：载脂蛋白Ｅ（ａｐｏＥ）基因多态性对缺血性脑血管疾病（ＩＣＶＤ）发生的影响。方法：临床筛选６７例缺血性脑血管病病人，利用聚合酶链反应（ＰＣＲ）技术进行ａｐｏＥ基因位点的扩增，然后用Ｈｈａ　Ｉ酶切ＤＮＡ扩增产物，进行限制性片断长度多态性分析（ＲＦＬＰ），检测他们的ａｐｏＥ基因型，并与正常对照组比较，并同时检测血脂水平及血流变学指标。结果：ＩＣＶＤ组与健康对照组ａｐｏＥ基因型分布无显著差异，不同类型ＩＣＶＤ组ａｐｏＥ基因型分布亦无显著差异．结论：ａｐｏＥ基因多态性不是缺血性脑血管病的危险因素。

引用

页码：29 / 31

页数：3

共 8 条

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