低分子肝素治疗急性缺血性中风疗效和安全性

被引：60

作者：

吴笃初

乔健

姚景莉

吕传真

机构：

[1] 上海医科大学华山医院神经科!上海

来源：

中国临床药学杂志 | 1998年 / 03期

关键词：

急性缺血性中风; 低分子右旋糖苷; 低分子肝素; 疗效; 安全性;

D O I：

10.19577/j.cnki.issn10074406.1998.03.004

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

目的:评价低分子肝素(LMWH)治疗急性缺血性中风的疗效和安全性.方法:入选病例均用低分子右旋糖苷作基础治疗,治疗组加用LMWH.治疗组:3例进展型短暂脑缺血发作(TIA)及31例发病48h内脑梗死,LMWH4100anti-XaIU,bid,腹壁sc,连续10d.对照组:31例脑梗死.采用中风评分法在用药后1mo进行总评价.用发光底物法测定LMWH浓度.结果:3例TIA症状很快缓解.治疗组的总有效率(90.3%)明显优于对照组(64.5%),P<0.05.同时,起病24h内开始LMWH治疗的显效率(84.2%)优于起病24～48h才开始LMWH治疗的显效率(41.7%),P<0.02.高峰和低谷血药浓度分别为(0.32±0.17)及(0.26±0.19)anti-XaIU.未发现出血倾向.结论:低分子肝素治疗急性缺血性中风是安全有效的.

引用

页码：111 / 114

页数：4

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