重复经颅磁刺激治疗脑卒中后抑郁的临床疗效及磁共振波谱分析

被引：3

作者：

周丽华

田青

陈勋

周倩

叶鸿

机构：

[1] 黄石市中心医院老年病科

来源：

临床荟萃 | 2016年 / 31卷 / 05期

关键词：

脑血管意外; 抑郁; 磁疗法;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

目的探讨不同频率的重复经颅磁刺激(rTMS)对脑卒中后抑郁(PSD)的治疗效果,氢质子磁共振波谱(1 H-MRS)对于该疗效的评价价值。方法连续选取脑卒中后抑郁患者73例,根据中国精神疾病分类方案与诊断标准第3版,以分层区组随机化分组法,将患者分为高频刺激组(24例),低频刺激组(24例),假刺激组(25例)。前2组分别接受rTMS高频刺激和低频刺激治疗,分别在入组时和治疗4周后给予汉密顿抑郁量表(HAMD)检查,假刺激组给予和高频刺激组相同频率的声音,但是没有磁刺激,并在治疗4周后给予1 H-MRS检查,对各组结果进行统计分析。结果 1治疗后,高频刺激组HAMD评分(13.5±1.6)分和低频刺激组(13.1±1.7)分降低,两组之间差异无统计学意义,但两组与假刺激组(16.3±1.4)分比较差异有统计学意义(P<0.01),假刺激组HAMD评分改善不显著。2治疗后,3组患者之间双侧额叶、丘脑和海马的Cho/Cr比值差异无统计学意义(P>0.05)。结论 rTMS高频和低频刺激均能改善PSD患者抑郁状况,未发现两者之间有显著差异。

引用

页码：532 / 535

页数：4

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